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Azelastine: Wikis


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Systematic (IUPAC) name
4-[(4-chlorophenyl)methyl]-2- (1-methylazepan-4-yl)-phthalazin-1-one
CAS number 58581-89-8
ATC code R01AC03 R06AX19, S01GX07
PubChem 2267
DrugBank APRD00813
ChemSpider 2180
Chemical data
Formula C22H24ClN3O 
Mol. mass 381.898 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 40% (intranasal)
Half life 22 hours
Therapeutic considerations
Pregnancy cat. C(US)
Legal status Rx Only (US)
Routes intranasal, ocular
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Azelastine is an antihistamine and mast cell stabilizer available as a nasal spray (Astelin or Astepro) for hay fever and as eye drops (Optivar) for allergic conjunctivitis.


Side effects

Nasal spray

Side effects of azelastine nasal spray vary somewhat depending on the condition being treated. The most common side effects include bitter taste, headache, rhinitis, nose bleed, and somnolence. Adults being treated for vasomotor rhinitis may also experience dysesthesia and sinusitis. Additional side effects experienced by adults being treated for seasonal allergies include nasal burning, pharyngitis, dry mouth, paroxysmal sneezing, nausea, fatigue, dizziness, and weight gain.[1]

External links


  1. ^ Astelin prescribing information

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