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Azelnidipine: Wikis

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Azelnidipine
Systematic (IUPAC) name
O3-[1-[di(phenyl)methyl]azetidin-3-yl] O5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Identifiers
CAS number 123524-52-7
ATC code none
PubChem 65948
ChemSpider 59352
Chemical data
Formula C 33H34N4O6  
Mol. mass 582.64 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Azelnidipine (INN; marketed under the brand name Calblock) is a dihydropyridine calcium channel blocker. It is sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. Unlike nicardipine, it has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.[1]

References

  1. ^ Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (September 1989). "Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker" ( – Scholar search). Jpn. J. Pharmacol. 51 (1): 57–64. doi:10.1254/jjp.51.57. PMID 2810942. http://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/51.57?from=PubMed.  
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