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B-cell prolymphocytic leukemia: Wikis


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B-cell prolymphocytic leukemia
Classification and external resources

ICD-O: M9833/3
MeSH D054403

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.

It can involve deletions from chromosome 11 and chromosome 13.[1]

It has been suggested that some cases may represent a variant of mantle cell lymphoma.[2]

It has a relatively poor prognosis.[3]



A case has been described as CD20+, CD22+, and CD5-.[4]

It can also be CD5+.[5]

Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.[6]


Splenic irradiation has been used in the treatment.[7]

See also


  1. ^ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). "Frequent deletions at 11q 23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)". Leukemia 14 (3): 427–30. doi:10.1038/sj.leu.2401644. PMID 10720137.  
  2. ^ Ruchlemer R, Parry-Jones N, Brito-Babapulle V, et al. (May 2004). "B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia". Br. J. Haematol. 125 (3): 330–6. doi:10.1111/j.1365-2141.2004.04913.x. PMID 15086413.  
  3. ^ Del Giudice I, Davis Z, Matutes E, et al. (2006). "IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)". Leukemia 20 (7): 1231–7. doi:10.1038/sj.leu.2404238. PMID 16642047.  
  4. ^ Yamamoto K, Hamaguchi H, Nagata K, Shibuya H, Takeuchi H (April 1998). "Splenic irradiation for prolymphocytic leukemia: is it preferable as an initial treatment or not?". Jpn. J. Clin. Oncol. 28 (4): 267–9. doi:10.1093/jjco/28.4.267. PMID 9657013.  
  5. ^ "Pathology". Retrieved 2009-01-31.  
  6. ^ Crisostomo RH, Fernandez JA, Caceres W (May 2007). "Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia". Leuk. Res. 31 (5): 699–701. doi:10.1016/j.leukres.2006.06.010. PMID 16997373.  
  7. ^ Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S (December 2008). "Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia" ( – Scholar search). Rinsho Ketsueki 49 (12): 1619–22. PMID 19110524.  


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