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Beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

PDB rendering based on 1v82.
Available structures
1v82, 1v83, 1v84
Symbols B3GAT1; CD57; GLCATP; GlcAT-P; GlcUAT-P; HNK-1; LEU7; NK-1
External IDs OMIM151290 MGI1924148 HomoloGene49551 GeneCards: B3GAT1 Gene
RNA expression pattern
PBB GE B3GAT1 219521 at tn.png
More reference expression data
Species Human Mouse
Entrez 27087 76898
Ensembl ENSG00000109956 ENSMUSG00000045994
UniProt Q9P2W7 Q5DTF9
RefSeq (mRNA) NM_018644 NM_029792
RefSeq (protein) NP_061114 NP_084068
Location (UCSC) Chr 11:
133.75 - 133.79 Mb
Chr 9:
26.48 - 26.51 Mb
PubMed search [1] [2]

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 is an enzyme that in humans is encoded by the B3GAT1 gene.[1]

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.[1]

In immunology, the CD57 antigen (CD stands for cluster of differentiation) is a protein which is also called HNK1 (human natural killer-1) or LEU7. It is a neuronally expressed adhesion molecule with a carbohydrate epitope that contains a sulfoglucuronyl residue.[2]


  1. ^ a b "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".  
  2. ^ Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope". Genomics 65 (2): 166–73. doi:10.1006/geno.2000.6152. PMID 10783264.  

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Tone Y, Kitagawa H, Imiya K, et al. (1999). "Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.". FEBS Lett. 459 (3): 415–20. doi:10.1016/S0014-5793(99)01287-9. PMID 10526176.  
  • Mitsumoto Y, Oka S, Sakuma H, et al. (2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.". Genomics 65 (2): 166–73. doi:10.1006/geno.2000.6152. PMID 10783264.  
  • Pedersen LC, Tsuchida K, Kitagawa H, et al. (2000). "Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.". J. Biol. Chem. 275 (44): 34580–5. doi:10.1074/jbc.M007399200. PMID 10946001.  
  • Cebo C, Durier V, Lagant P, et al. (2002). "Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands.". J. Biol. Chem. 277 (14): 12246–52. doi:10.1074/jbc.M106816200. PMID 11788581.  
  • Ouzzine M, Gulberti S, Levoin N, et al. (2002). "The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues.". J. Biol. Chem. 277 (28): 25439–45. doi:10.1074/jbc.M201912200. PMID 11986319.  
  • Brenchley JM, Karandikar NJ, Betts MR, et al. (2003). "Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells.". Blood 101 (7): 2711–20. doi:10.1182/blood-2002-07-2103. PMID 12433688.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Jirásek T, Hozák P, Mandys V (2003). "Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal carcinoids: immunohistochemical and confocal laser scanning microscopy study.". Neoplasma 50 (1): 1–7. PMID 12687271.  
  • Jeffries AR, Mungall AJ, Dawson E, et al. (2004). "beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation.". Mol. Psychiatry 8 (7): 654–63. doi:10.1038/ PMID 12874601.  
  • Chochi K, Ichikura T, Majima T, et al. (2004). "The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer.". Oncol. Rep. 10 (5): 1443–8. PMID 12883721.  
  • Kakuda S, Shiba T, Ishiguro M, et al. (2004). "Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1.". J. Biol. Chem. 279 (21): 22693–703. doi:10.1074/jbc.M400622200. PMID 14993226.  
  • Matsubara K, Yura K, Hirata T, et al. (2005). "Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report.". Pediatric hematology and oncology 21 (7): 677–82. doi:10.1080/08880010490501105. PMID 15626024.  
  • Ibegbu CC, Xu YX, Harris W, et al. (2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57.". J. Immunol. 174 (10): 6088–94. PMID 15879103.  
  • Assouti M, Vynios DH, Anagnostides ST, et al. (2006). "Collagen type IX and HNK-1 epitope in tears of patients with pseudoexfoliation syndrome.". Biochim. Biophys. Acta 1762 (1): 54–8. doi:10.1016/j.bbadis.2005.09.005. PMID 16257185.  
  • Barré L, Venkatesan N, Magdalou J, et al. (2006). "Evidence of calcium-dependent pathway in the regulation of human beta1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesis.". Faseb J. 20 (10): 1692–4. doi:10.1096/fj.05-5073fje. PMID 16807373.  
  • Sada-Ovalle I, Torre-Bouscoulet L, Valdez-Vázquez R, et al. (2007). "Characterization of a cytotoxic CD57+ T cell subset from patients with pulmonary tuberculosis.". Clin. Immunol. 121 (3): 314–23. doi:10.1016/j.clim.2006.08.011. PMID 17035093.  

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