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Beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)

PDB rendering based on 2d0j.
Available structures
2d0j
Identifiers
Symbols B3GAT2; GLCATS; GlcAT-S; KIAA1963; MGC138535
External IDs OMIM607497 MGI2389490 HomoloGene50574 GeneCards: B3GAT2 Gene
Orthologs
Species Human Mouse
Entrez 135152 280645
Ensembl ENSG00000112309 ENSMUSG00000026156
UniProt Q9NPZ5 Q3UWJ6
RefSeq (mRNA) NM_080742 XM_981748
RefSeq (protein) NP_542780 XP_986842
Location (UCSC) Chr 6:
71.62 - 71.72 Mb
Chr 1:
23.72 - 23.8 Mb
PubMed search [1] [2]

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.[1][2]

The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.[2]

References

  1. ^ Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope". Gene 296 (1-2): 29-36. PMID 12383500.  
  2. ^ a b "Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=135152.  

Further reading

  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Marcos I, Galán JJ, Borrego S, Antiñolo G (2003). "Cloning, characterization, and chromosome mapping of the human GlcAT-S gene.". J. Hum. Genet. 47 (12): 677–80. doi:10.1007/s100380200103. PMID 12522689.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Kakuda S, Oka S, Kawasaki T (2004). "Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli.". Protein Expr. Purif. 35 (1): 111–9. doi:10.1016/j.pep.2003.12.021. PMID 15039073.  
  • Kakuda S, Sato Y, Tonoyama Y, et al. (2005). "Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.". Glycobiology 15 (2): 203–10. doi:10.1093/glycob/cwi001. PMID 15470230.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Shiba T, Kakuda S, Ishiguro M, et al. (2006). "Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope.". Proteins 65 (2): 499–508. doi:10.1002/prot.21118. PMID 16897771.  
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