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BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
Identifiers
Symbols BAMBI; NMA
External IDs OMIM604444 MGI1915260 HomoloGene8215 GeneCards: BAMBI Gene
Orthologs
Species Human Mouse
Entrez 25805 68010
Ensembl ENSG00000095739 ENSMUSG00000024232
UniProt Q13145 Q9D0L6
RefSeq (mRNA) NM_012342 NM_026505
RefSeq (protein) NP_036474 NP_080781
Location (UCSC) Chr 10:
29.01 - 29.01 Mb
Chr 18:
3.51 - 3.52 Mb
PubMed search [1] [2]

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[1][2]

Contents

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[1]

References

  1. ^ a b "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25805.  
  2. ^ Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.  

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.  
  • Lin Z, Gao C, Ning Y, et al. (2008). "The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.". J. Biol. Chem. 283 (48): 33053-8. doi:10.1074/jbc.M804039200. PMID 18838381.  
  • Sekiya T, Oda T, Matsuura K, Akiyama T (2004). "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling.". Biochem. Biophys. Res. Commun. 320 (3): 680-4. doi:10.1016/j.bbrc.2004.06.017. PMID 15240101.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fritzmann J, Morkel M, Besser D, et al. (2009). "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.". Gastroenterology 137 (1): 165-75. doi:10.1053/j.gastro.2009.03.041. PMID 19328798.  
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239-46. doi:10.1006/excr.2000.4948. PMID 10942595.  
  • Khin SS, Kitazawa R, Win N, et al. (2009). "BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer.". Int. J. Cancer 125 (2): 328-38. doi:10.1002/ijc.24318. PMID 19326429.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.  
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.". Mol. Vis. 8: 196-204. PMID 12107411.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Sekiya T, Adachi S, Kohu K, et al. (2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells.". J. Biol. Chem. 279 (8): 6840-6. doi:10.1074/jbc.M310876200. PMID 14660579.  
  • Togo N, Ohwada S, Sakurai S, et al. (2008). "Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer.". World J. Gastroenterol. 14 (31): 4880-8. PMID 18756595.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.  
  • Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.  
  • Degen WG, Weterman MA, van Groningen JJ, et al. (1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts.". Int. J. Cancer 65 (4): 460-5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Simple English

Bambi
Directed by David Dodd Hand
Produced by Walt Disney
Written by Felix Salten (book)
Larry Morey (story adaptation)
Perce Pearce (story direction)
Gustaf Tenggren (illustration)
Starring Bobby Stewart
Donnie Dunagan
Hardie Albright
John Sutherland
Paula Winslowe
Peter Behn
Tim Davis
Sam Edwards
Will Wright
Cammie King
Ann Gillis
Fred Shields
Stan Alexander
Sterling Holloway
Music by Frank Churchill
Edward H. Plumb
Distributed by RKO Radio Pictures
Release date(s) August 13, 1942
Running time 69 minutes
Country USA
Language English
Budget Over $2,000,000[1]
Followed by Bambi II (2006)

Bambi is a cartoon movie. The people who made the movie were paid by Walt Disney. The fifth movie in the Disney animated featuers canon, the movie is lossely based on the 1923 book Bambi, A Life in the Woods by Austrian writer Felix Salten. The story is about a baby deer, named Bambi, who learns to grow up in the wild after his mother is shot by hunters. The main characters are Bambi, a white-tailed deer, his parents (the Great Prince of the forest and his unnamed mother), and his friends Thumper (a pink-nosed rabbit), Flower (a skunk), and his childhood friend and future wife, Faline.

For the movie, Disney changed Bambi's species into a white-tailed deer from his original species of Roe Deer, since roe deer don't live in the United States, and the white-tailed deer is more familiar to Americans. The movie received three Academy Award nominations for Best Sound, Best Song for "Love is a song" and Original Music Score. The term "Bambi eyes" was made in response to the movie to describe an innocent look that people can make with their eyes to generate sympathy. On March 1, 2005, a 2-disc Platinum Edition Disney DVD was released, featuring a competely refreashed version of the movie[2]. First released to movie theatres by RKO Radio Pictures on August 13, 1942, Bambi has started many controversies do to its dark tones and although the film received good reviews, it was criticized as being inappropriate for children because of the death of Bambi's mother, as well as the scary violence of the hunting scenes, dog attacks, and the forest fire climax. Also, it did poorly at the box office during its original release.[3] In June 2008, the American Film Institute listed its "Ten top Ten", the best ten movies in ten "classic" American film genres. After voting from over 1,500 people, Bambi was said to be the third best animated movie.

Contents

The story

The movie starts with a wise old owl that tells about a little fawn called Bambi that is born in the woods. He spends his first days of life exploring the forest around him. He makes a friend called Thumper, who is a rabbit. Bambi learns new things everyday. He discovers birds ("bird" becomes his first word), butterflies, rain, the meadow, and also sees his father (the Great Prince of the Forest) for the first time. So, to put it simply, the first half of the movie mainly involves Bambi's childhood, such as a walk through the woods, a day in the meadow, and his first encounter with snow. The most famous part of the movie involves the death of a certain character. This is where people cry in the movie. Bambi and his mother have trouble finding food. One day, Bambi's mother finds a patch of grass, and they eat. We now hear scary music (Man's theme, a low-three mort hum) and Bambi's mother senses danger. She tells Bambi to run, and as they run across an icy field, she screams "Faster! Faster, Bambi! Don't look back! Keep running! Keep running!" We see Bambi make it but we hear a gunshot. Bambi makes it back to the den but finds that his mother is no longer there. He wanders around, desperately calling for her, and bumps into his father, the Great Prince, who tells him that "your mother can't be with you anymore". Bambi follows his father into the woods, taking one last look behind him. The next spring (Bambi II covers up this gap), we see Bambi and his friends as adults. They meat up with a wise old owl, called Friend Owl, who tells them of the dangers of becoming Template:Broken wiki link (falling in love). They make vows not to become twitterpated, but are in love at first sight in no time. Bambi falls in love with his old childhold friend Faline, and is happily dancing in the clouds until another deer steps in the way. He tries to get Faline to go with him, but Bambi won't stand this and gets into a fight with this deer. Bambi of course wins, and goes on a date with Faline. The Man comes back and makes more trouble for the animals and Bambi saves Faline from a pack of angry dogs. A forrest fire comes, and nearly destroys everything. Bambi has trouble getting up, but his father helps him. They both make it to an island where the animals have gathered. The following spring, everybody goes to see Bambi and Faline's new fawns, with the wise owl saying that Bambi should be proud. The Great Prince literally steps down from his current place as king, and Bambi is left standing proudly as a reprise of the beginning song, Love is a Song, is sung by a chorus.

Production

Walt Disney wanted to achieve realistic detail in this animated movie. The artists heard teachings from animal experts, and visited the Los Angeles Zoo.[4] A pair of fawns (named Bambi and Faline) were shipped from the area of present day Baxter State Park in Maine to the studio so that the artists could see first-hand the movement of these animals. The source of these fawns, from the Eastern United States, gave the company the idea to change Felix Salten's Roe Deer to a white-tailed deer.[5] The background of the movie was also the Eastern woodlands — one of the earliest and best known artists for the Disney studio, Maurice "Jake" Day spent several weeks in the Vermont and Maine forests, sketching and photographing deer, fawns, and the surrounding wilderness areas.[6]

Voice cast

Actor Role(s)
Bobby Stewart Baby Bambi
Donnie Dunagan Young Bambi
Hardie Albright Adolescent Bambi
John Sutherland Adult Bambi
Paula Winslowe Bambi's Mother and Pheasant
Peter Behn Young Thumper
Tim Davis Adolescent Thumper, Adolescent Flower
Sam Edwards Adult Thumper
Stan Alexander Young Flower
Sterling Holloway Adult Flower
Will Wright Friend Owl
Cammie King Young Faline
Ann Gillis Adult Faline
Fred Shields Great Prince of the Forest
Thelma Boardman Girl Bunny, Quail Mother and Frightened Pheasant
Mary Lansing Aunt Ena, Mrs. Possum, Pheasant
Margaret Lee Mrs. Rabbit
Otis Harlan Mr. Mole
Marion Darlington Bird calls
Clarence Nash Bullfrog
Stuart Erwin Tree Squirrel

Characters

Characters from Bambi

  • Bambi, voiced by Bobby Stewart, Donnie Dunagan, and Alexander Gould, is the main character in the story. In the first movie, he is often cute and innocent. In the second movie, saddened by the loss of his mother, Bambi tries to live without her. Throughout the second movie he constantly tries to win the attention, support, and love he needs from his father.
  • Thumper, voiced by Peter Behn, Tim Davis, and Brendon Baerg, is Bambi's main best friend. In the first movie, he helps Bambi discover new things, like "bird", "flower", and "butterfly". In Bambi II, he helps Bambi try to impress his father. Thumper also spends much of his time running away from his four sisters as he finds them annoying.
  • Flower , voiced by Stan Alexander, Sterling Holloway, and Nicky Jones, is a bashful skunk and Bambi's other best friend. In Bambi II, Flower also helps Bambi try to impress his father and is scared of turtles.
  • The Great Prince of the Forest, voiced by Fred Shields in Bambi and Patrick Stewart in Bambi II, is Bambi's father. Throughout the first movie, the Great Prince is always never around. In Bambi II, he feels that a father is not what Bambi needs, and he tries to send Bambi away rather than teach him the ways of having the crown of the forest. Things are not helped much by the fact that he is used to a quiet life. In spite of this, he learns how to become a loving father and friend to Bambi.
  • Faline, voiced by Cammie King, Ann Gillis, and Andrea Bowen, is one of Bambi's childhood friends and eventually grows up to become his wife. In Bambi II, her effect on Bambi has changed little since the first movie. Whenever she is around, Bambi generally becomes tongue-tied and very clumsy. However, when Ronno tries to force Faline to leave, Bambi stands up for her, in what looks like a back-to-back screen-shot of the mirroring scene in the original. Also, just like in Bambi, Ronno and Bambi have a fight, only this time much shorter. The scene is a direct mirroring of the scene in the original, and the fight is broken only after Meana comes in. Ronno, still angry, bumps into Bambi causing Meana to fall into one of Man's traps. Then Bambi has to fight a pack of dogs just like he did the original.
  • Friend Owl, voiced by Will Wright in Bambi and Keith Ferguson, in Bambi II, is a friendly but easy to annoy old owl. Thumper and his baby sisters are always waking him up going "Wake Up! Wake Up, Friend Owl!" He will respond going "Oh, NOW what?!" (played for laughs). In Bambi II, Friend Owl is asked by the Great Prince to find a suitable doe to raise Bambi.
  • Bambi's mother, voiced by Paula Winslowe, is Bambi's main parent thoughtout the first movie. Her death has saddened many. In Bambi II, she is voiced by Carolyn Hennes, and makes one small appearance in a dream sequence in which she talks to Bambi.
  • The Hunter, is a poacher who tries to shoot Bambi. While not successful, he instead shoots Bambi's mother, resulting in the most well known scene of the movie. He is the movie's antagonist even though he is never seen.

Characters from Bambi II

  • Ronno, voiced by Anthony Ghannam, fights Bambi for the love of Faline and is generally full of annoyence. According to production notes, Ronno was the unnamed deer who fought Bambi in the original movie for Faline as well.
  • The Groundhog, voiced by Brian Pimental (who also directed Bambi II), is the focus of the forest's Groundhog Day celebrations. On February 2 each year, the Groundhog comes out into the forest square and determines whether or not winter will last a few more weeks. Yet, he hates the job and is scared of his own shadow, complaining that "my nerves just can't take it any more."
  • The Porcupine, voiced by Brian Pimental (again, director), is a minor character who is extremely protective of his land. As the forest's troll, he takes joy in keeping animals away from his log home. Bambi's first encounter with the Porcupine ends in a painful and humiliating defeat for Bambi. Their second confrontation leads to the Porcupine being used to fight of the dogs. The porcupine also causes Bambi to accidentally kiss Faline at the end of the movie.
  • Mena, voiced by Cree Summer (who also voiced Kida in Disney's Atlantis: The Lost Empire), is the doe Friend Owl finds as a mother for Bambi, in order to allow the Great Prince to focus his attention on protecting the forest. Friend Owl found her just when Bambi and the Great Prince were beginning to bond, nearly ruining the relationship. She grew up with Bambi's mother.

Release history

Bambi was released in theaters in 1942, during World War II, and was Disney's fifth full-length animated movie. The famous art direction of Bambi was due to the influence of Tyrus Wong, a former painter who provided eastern and painterly influence to the backgrounds. Bambi was re-released to theaters in 1947, 1957, 1966, 1975, 1982, and 1988. It was released on VHS in 1989 (Classics Version), 1997 (Masterpiece Collection Version), and digitally remastered and restored for the March 1, 2005 Platinum Edition DVD.[2] The Platinum Edition DVD went into the "Disney Vault" on January 31 2007.[7] The Masterpiece Version was the first Disney Video to be THX certified. In the 2005 Platinum Edition DVD, the RKO logo was replaced by the cut-short 1990 Walt Disney Pictures logo with RKO music.

Release dates

United States

Home Video Releases

  • June 29, 1990 VHS and Laserdisc released by Walt Disney Classics
  • May 1, 1992 VHS and Laserdisc-50th Anniversary Edition- released by Walt Disney Classics
  • October 7, 1997 VHS-55th Anniversary Edition- released by Walt Disney Masterpiece Collection
  • March 1, 2005 Platinum Edition DVD
  • Spring 2011 Bluray Diamond Edition and 2-Disc DVD Set
  • February 2013 Bluray and 2-Disc DVD-70th Anniversary Edition

International

Soundtrack listing

  1. Main Title (Love Is A Song)
  2. Morning In The Woods/The Young Prince/Learning To Walk
  3. Exploring/Say Bird/Flower
  4. Little April Shower
  5. The Meadow/Bambi Sees Faline/Bambi Gets Annoyed
  6. Gallop Of The Stags/The Great Prince Of The Forest/Man
  7. Autumn/The First Snow/Fun On The Ice
  8. The End Of Winter/New Spring Grass/Tragedy In The Meadow
  9. Wintry Winds
  10. Let's Sing A Gay Little Spring Song
  11. It Could Even Happen To Flower
  12. Bambi Gets Twitterpated/Stag Fight
  13. Looking For Romance (I Bring You A Song)
  14. Man Returns
  15. Fire/Reunion/Finale
  16. Rain Drops (Demo Recording)
  17. Bonus Interview – Introduced by Richard Kiley: Walt Disney
  18. Bonus Interview – Introduced by Richard Kiley: Ollie Johnston And Frank Thomas
  19. Bonus Interview – Introduced by Richard Kiley: Henry Mancini
  20. Bonus Interview - Introduced by Richard Kiley; Richard and Robert Sherman

Similarities with The Lion King

52 years following the release of Bambi, the movie inspired certain plot ideas for Disney's 32 animated movie, The Lion King. The main characters in the movie are cast as African lions, as Simba, a young lion cub, learns his place in the "Circle of Life". Likewise to Bambi, Simba loses a parent in the course of the film, however, there are no humans noted in the movie, as Simba's father, Mufasa, dies in a wildebeest stampede. Simba also is childhood friends with his intended mate (here named Nala), and they are made aware of their arranged marriage, a topic that was beyond them at the time. Simba's uncle, Scar, is the main villain in the movie, who killed Mufasa, and also planned to kill Simba, in order to be king. Simba flees the kingdom in shame, only to return to challenge his uncle and eventually become the lion king.

Midquel

Bambi II, a midquel to Bambi, was released in the United States on February 7, 2006. Taking place in the middle of Bambi, it shows the Great Prince of the Forest struggling to raise the motherless Bambi, and Bambi's doubts about his father's love. While the movie was a direct-to-video release in countries like the United States, Japan, Canada, mainland China, Hong Kong and Taiwan, it was a theatrical release in some countries like the United Kingdom, France, Austria, Mexico, Dominican Republic, Brazil, Australia and some other European countries.

Titles in other languages

References

  1. Kevin Jackson 'Tears of a fawn', The Independent, February 6, 2005.
  2. 2.0 2.1 How They Restored Bambi, Monsters and Critics.
  3. Kevin Jackson 'Tears of a fawn', The Independent, February 6, 2005.
  4. Walt Disney Collection: Walt's Masterworks — Bambi.
  5. The Trouble with Bambi: Walt Disney's Bambi and the American Vision of Nature by Ralph H. Lutts: From 'Forest and Conservation History' 36 (October 1992)
  6. Maurice E. Day, Animator, 90; Drew Deer for Movie 'Bambi': Obituary in the New York Times, published May 19, 1983)
  7. IGN.

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