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BATF (gene): Wikis

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Basic leucine zipper transcription factor, ATF-like
Identifiers
Symbols BATF; B-ATF; BATF1; SFA-2
External IDs MGI1859147 HomoloGene4666 GeneCards: BATF Gene
RNA expression pattern
PBB GE BATF 205965 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10538 53314
Ensembl ENSG00000156127 ENSMUSG00000034266
UniProt Q16520 O35284
RefSeq (mRNA) NM_006399 NM_016767
RefSeq (protein) NP_006390 NP_058047
Location (UCSC) Chr 14:
75.06 - 75.08 Mb
Chr 12:
86.58 - 86.6 Mb
PubMed search [1] [2]

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[1][2][3]

Contents

Function

The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[3]

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[4]

Interactions

BATF (gene) has been shown to interact with IFI35.[5]

References

  1. ^ Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (December 1995). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene 11 (11): 2255–65. PMID 8570175.  
  2. ^ Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.  
  3. ^ a b "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10538.  
  4. ^ Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM (July 2009). "The AP-1 transcription factor Batf controls T(H)17 differentiation". Nature 460 (7253): 405–9. doi:10.1038/nature08114. PMID 19578362. Lay summary – eurekalert.org (2009-07-16).  
  5. ^ Wang, X; Johansen L M, Tae H J, Taparowsky E J (Dec. 1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. (UNITED STATES) 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. ISSN 0006-291X. PMID 8954125.  

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ (2003). "Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.". Biochem. J. 374 (Pt 2): 423–31. doi:10.1042/BJ20030455. PMID 12809553.  
  • Johansen LM, Deppmann CD, Erickson KD, et al. (2003). "EBNA2 and activated Notch induce expression of BATF.". J. Virol. 77 (10): 6029–40. doi:10.1128/JVI.77.10.6029-6040.2003. PMID 12719594.  
  • Williams KL, Zullo AJ, Kaplan MH, et al. (2003). "BATF transgenic mice reveal a role for activator protein-1 in NKT cell development.". J. Immunol. 170 (5): 2417–26. PMID 12594265.  
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos.". Oncogene 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209.  
  • Meyer NP, Johansen LM, Tae HJ, et al. (1998). "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1.". Mamm. Genome 9 (10): 849–52. doi:10.1007/s003359900881. PMID 9745044.  
  • Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1997). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors.". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.  
  • Hasegawa H, Utsunomiya Y, Kishimoto K, et al. (1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes.". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.  
  • Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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