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B-cell CLL/lymphoma 11B (zinc finger protein)
Identifiers
Symbols BCL11B; RIT1; CTIP-2; CTIP2; hRIT1-alpha
External IDs OMIM606558 MGI1929913 HomoloGene10974 GeneCards: BCL11B Gene
RNA expression pattern
PBB GE BCL11B 219528 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64919 58208
Ensembl ENSG00000127152 ENSMUSG00000048251
UniProt Q9C0K0 Q3TEG9
RefSeq (mRNA) NM_022898 NM_001079883
RefSeq (protein) NP_075049 NP_001073352
Location (UCSC) Chr 14:
98.71 - 98.81 Mb
Chr 12:
108.36 - 108.45 Mb
PubMed search [1] [2]

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[1][2][3]

Contents

Function

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[3]

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.[4]

Interactions

BCL11B has been shown to interact with COUP-TFI.[5]

References

  1. ^ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ (Nov 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood 98 (12): 3413–20. PMID 11719382.  
  2. ^ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B Jr, Martinez B, Crofoot K, Filtz TM, Leid M (Oct 2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". J Biol Chem 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMID 16950772.  
  3. ^ a b "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64919.  
  4. ^ Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4278–83. doi:10.1073/pnas.0900568106. PMID 19251658. Lay summary – BBC News.  
  5. ^ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMID 10744719.  

Further reading

  • Avram D, Fields A, Pretty On Top K, et al. (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMID 10744719.  
  • Avram D, Fields A, Senawong T, et al. (2003). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein.". Biochem. J. 368 (Pt 2): 555–63. doi:10.1042/BJ20020496. PMID 12196208.  
  • Wakabayashi Y, Inoue J, Takahashi Y, et al. (2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas.". Biochem. Biophys. Res. Commun. 301 (2): 598–603. doi:10.1016/S0006-291X(02)03069-3. PMID 12565905.  
  • Rohr O, Lecestre D, Chasserot-Golaz S, et al. (2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells.". J. Virol. 77 (9): 5415–27. doi:10.1128/JVI.77.9.5415-5427.2003. PMID 12692243.  
  • Senawong T, Peterson VJ, Avram D, et al. (2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.". J. Biol. Chem. 278 (44): 43041–50. doi:10.1074/jbc.M307477200. PMID 12930829.  
  • Bezrookove V, van Zelderen-Bhola SL, Brink A, et al. (2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.". Cancer Genet. Cytogenet. 149 (1): 72–6. doi:10.1016/S0165-4608(03)00302-9. PMID 15104287.  
  • MacLeod RA, Nagel S, Drexler HG (2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia.". Cancer Genet. Cytogenet. 153 (1): 88–9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104.  
  • Przybylski GK, Dik WA, Wanzeck J, et al. (2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL.". Leukemia 19 (2): 201–8. doi:10.1038/sj.leu.2403619. PMID 15668700.  
  • Cismasiu VB, Adamo K, Gecewicz J, et al. (2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter.". Oncogene 24 (45): 6753–64. doi:10.1038/sj.onc.1208904. PMID 16091750.  
  • Marban C, Suzanne S, Dequiedt F, et al. (2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.". Embo J. 26 (2): 412–23. doi:10.1038/sj.emboj.7601516. PMID 17245431.  
  • Nagel S, Scherr M, Kel A, et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.". Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.  
  • Kamimura K, Mishima Y, Obata M, et al. (2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages.". Oncogene 26 (40): 5840–50. doi:10.1038/sj.onc.1210388. PMID 17369851.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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