The Full Wiki

BCL6: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
B-cell CLL/lymphoma 6 (zinc finger protein 51)

PDB rendering based on 1r28.
Available structures
1r28, 1r29, 1r2b
Identifiers
Symbols BCL6; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
External IDs OMIM109565 MGI107187 HomoloGene7640 GeneCards: BCL6 Gene
RNA expression pattern
PBB GE BCL6 203140 at tn.png
PBB GE BCL6 215990 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 604 12053
Ensembl ENSG00000113916 ENSMUSG00000022508
UniProt P41182 Q544F9
RefSeq (mRNA) NM_001706 NM_009744
RefSeq (protein) NP_001697 NP_033874
Location (UCSC) Chr 3:
188.92 - 188.95 Mb
Chr 16:
23.88 - 23.9 Mb
PubMed search [1] [2]

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene.[1]

Contents

Interactions

BCL6 has been shown to interact with Histone deacetylase 5,[2] HDAC1,[3][4] HDAC7A,[2] ZBTB7A,[5] Zinc finger and BTB domain-containing protein 16,[6] HDAC4,[2] Nuclear receptor co-repressor 2,[7][8][4] BCOR,[7] C-jun[9] and IRF4.[10]

References

  1. ^ "Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=604.  
  2. ^ a b c Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. (United States) 277 (24): 22045–52. doi:10.1074/jbc.M201736200. ISSN 0021-9258. PMID 11929873.  
  3. ^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A (May. 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene (ENGLAND) 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. ISSN 0950-9232. PMID 9627120.  
  4. ^ a b Deltour, S; Guerardel C, Leprince D (Dec. 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (26): 14831–6. ISSN 0027-8424. PMID 10611298.  
  5. ^ Davies, J M; Hawe N, Kabarowski J, Huang Q H, Zhu J, Brand N J, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Jan. 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene (ENGLAND) 18 (2): 365–75. doi:10.1038/sj.onc.1202332. ISSN 0950-9232. PMID 9927193.  
  6. ^ Dhordain, P; Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The H D, Zelent A, Koken M H (Dec. 2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene (England) 19 (54): 6240–50. doi:10.1038/sj.onc.1203976. ISSN 0950-9232. PMID 11175338.  
  7. ^ a b Huynh, K D; Fischle W, Verdin E, Bardwell V J (Jul. 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. (UNITED STATES) 14 (14): 1810–23. ISSN 0890-9369. PMID 10898795.  
  8. ^ Wong, C W; Privalsky M L (Oct. 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. (UNITED STATES) 273 (42): 27695–702. ISSN 0021-9258. PMID 9765306.  
  9. ^ Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". J. Immunol. (United States) 169 (4): 1922–9. ISSN 0022-1767. PMID 12165517.  
  10. ^ Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. ISSN 0022-1007. PMID 10601358.  

Further reading

  • Ueda C, Akasaka T, Ohno H (2003). "Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications.". Leuk. Lymphoma 43 (7): 1375–81. doi:10.1080/10428190290033305. PMID 12389616.  
  • Niu H (2003). "The proto-oncogene BCL-6 in normal and malignant B cell development.". Hematological oncology 20 (4): 155–66. doi:10.1002/hon.689. PMID 12469325.  
  • Tokuhisa T (2003). "[A role for Bcl6 in immune memory development]". Tanpakushitsu Kakusan Koso 47 (16 Suppl): 2306–12. PMID 12518453.  
  • Ohno H (2004). "Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma.". Histol. Histopathol. 19 (2): 637–50. PMID 15024721.  
  • Pasqualucci L, Bereschenko O, Niu H, et al. (2004). "Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6.". Leuk. Lymphoma 44 Suppl 3: S5–12. PMID 15202519.  
  • Jardin F, Ruminy P, Bastard C, Tilly H (2007). "The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis.". Pathol. Biol. 55 (1): 73–83. doi:10.1016/j.patbio.2006.04.001. PMID 16815642.  

External links

See also



This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message