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B-cell CLL/lymphoma 6 (zinc finger protein 51)

PDB rendering based on 1r28.
Available structures
1r28, 1r29, 1r2b
Symbols BCL6; BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
External IDs OMIM109565 MGI107187 HomoloGene7640 GeneCards: BCL6 Gene
RNA expression pattern
PBB GE BCL6 203140 at tn.png
PBB GE BCL6 215990 s at tn.png
More reference expression data
Species Human Mouse
Entrez 604 12053
Ensembl ENSG00000113916 ENSMUSG00000022508
UniProt P41182 Q544F9
RefSeq (mRNA) NM_001706 NM_009744
RefSeq (protein) NP_001697 NP_033874
Location (UCSC) Chr 3:
188.92 - 188.95 Mb
Chr 16:
23.88 - 23.9 Mb
PubMed search [1] [2]

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene.[1]



BCL6 has been shown to interact with Histone deacetylase 5,[2] HDAC1,[3][4] HDAC7A,[2] ZBTB7A,[5] Zinc finger and BTB domain-containing protein 16,[6] HDAC4,[2] Nuclear receptor co-repressor 2,[7][8][4] BCOR,[7] C-jun[9] and IRF4.[10]


  1. ^ "Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)".  
  2. ^ a b c Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. (United States) 277 (24): 22045–52. doi:10.1074/jbc.M201736200. ISSN 0021-9258. PMID 11929873.  
  3. ^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A (May. 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene (ENGLAND) 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. ISSN 0950-9232. PMID 9627120.  
  4. ^ a b Deltour, S; Guerardel C, Leprince D (Dec. 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (26): 14831–6. ISSN 0027-8424. PMID 10611298.  
  5. ^ Davies, J M; Hawe N, Kabarowski J, Huang Q H, Zhu J, Brand N J, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Jan. 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene (ENGLAND) 18 (2): 365–75. doi:10.1038/sj.onc.1202332. ISSN 0950-9232. PMID 9927193.  
  6. ^ Dhordain, P; Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The H D, Zelent A, Koken M H (Dec. 2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene (England) 19 (54): 6240–50. doi:10.1038/sj.onc.1203976. ISSN 0950-9232. PMID 11175338.  
  7. ^ a b Huynh, K D; Fischle W, Verdin E, Bardwell V J (Jul. 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. (UNITED STATES) 14 (14): 1810–23. ISSN 0890-9369. PMID 10898795.  
  8. ^ Wong, C W; Privalsky M L (Oct. 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. (UNITED STATES) 273 (42): 27695–702. ISSN 0021-9258. PMID 9765306.  
  9. ^ Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". J. Immunol. (United States) 169 (4): 1922–9. ISSN 0022-1767. PMID 12165517.  
  10. ^ Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. ISSN 0022-1007. PMID 10601358.  

Further reading

  • Ueda C, Akasaka T, Ohno H (2003). "Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications.". Leuk. Lymphoma 43 (7): 1375–81. doi:10.1080/10428190290033305. PMID 12389616.  
  • Niu H (2003). "The proto-oncogene BCL-6 in normal and malignant B cell development.". Hematological oncology 20 (4): 155–66. doi:10.1002/hon.689. PMID 12469325.  
  • Tokuhisa T (2003). "[A role for Bcl6 in immune memory development]". Tanpakushitsu Kakusan Koso 47 (16 Suppl): 2306–12. PMID 12518453.  
  • Ohno H (2004). "Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma.". Histol. Histopathol. 19 (2): 637–50. PMID 15024721.  
  • Pasqualucci L, Bereschenko O, Niu H, et al. (2004). "Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6.". Leuk. Lymphoma 44 Suppl 3: S5–12. PMID 15202519.  
  • Jardin F, Ruminy P, Bastard C, Tilly H (2007). "The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis.". Pathol. Biol. 55 (1): 73–83. doi:10.1016/j.patbio.2006.04.001. PMID 16815642.  

External links

See also

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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