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BMAL: Wikis


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aryl hydrocarbon receptor nuclear translocator-like
Symbol ARNTL
Entrez 406
HUGO 701
OMIM 602550
RefSeq NM_001178
UniProt O00327
Other data
Locus Chr. 11 p15
aryl hydrocarbon receptor nuclear translocator-like 2
Symbol ARNTL2
Entrez 56938
HUGO 18984
RefSeq NM_020183
UniProt Q8WYA4
Other data
Locus Chr. 12 p12.2-11.2

Bmal (brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like) is a gene that encodes proteins regulating circadian rhythm. BMAL proteins form part of a basic-helix-loop-helix transcription factor. BMAL-1 dimerizes with CLOCK in vivo and transactivates gene expression of Period and Timeless in drosophila by binding to E-box elements in their promoters.[1] BMAL1-CLOCK also regulates Cryptochrome genes (e.g. Cry1, Cry2) and Period genes (e.g. Per1, Per2, Per3).[2]

See also


  1. ^ Ishida N, Kaneko M, Allada R (1999). "Biological clocks". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8819–20. doi:10.1073/pnas.96.16.8819. PMID 10430850.  
  2. ^ Edery I (2000). "Circadian rhythms in a nutshell". Physiol. Genomics 3 (2): 59–74. PMID 11015601.  

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