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BRL-44408: Wikis

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BRL-44408
Systematic (IUPAC) name
2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole
Identifiers
CAS number 118343-19-4
ATC code  ?
PubChem 121850
Chemical data
Formula C 13H17N3  
Mol. mass 215.293 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

BRL-44408 is a drug used in scientific research which acts as a selective antagonist for the α2A adrenoreceptor.[1] It has been suggested as having potential therapeutic application in the treatment of extrapyramidal side effects produced by some antipsychotic medications.[2]

References

  1. ^ Alberts P (January 1993). "Subtype classification of presynaptic alpha 2-adrenoceptors". General Pharmacology 24 (1): 1–8. PMID 8387042.  
  2. ^ Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). "Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders". Neuroscience Letters 454 (2): 143–7. doi:10.1016/j.neulet.2009.03.001. PMID 19429072.  
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