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BU-48: Wikis


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Systematic (IUPAC) name
CAS number  ?
ATC code  ?
PubChem 10003114
Chemical data
Formula C 27H33NO4  
Mol. mass 435.554 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
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Legal status
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BU-48 is a drug which is used in scientific research. It is from the oripavine family, related to better known drugs such as etorphine and buprenorphine.

The parent compound from which BU-48 was derived (with N-methyl rather than methylcyclopropyl on the nitrogen and lacking the aliphatic hydroxyl group) is a powerful μ-opioid agonist 1000x more potent than morphine,[1] but in contrast BU-48 has only weak analgesic effects and instead acts primarily as a δ-opioid agonist. Its main effects are to produce convulsions,[2] but it may also have antidepressant effects.[3]


  1. ^ Lewis JW, Bentley KW, Cowan A. Narcotic Analgesics and Antagonists. Annual Reviews in Pharmacology 1971;11:241-270.
  2. ^ Broom DC, Guo L, Coop A, Husbands S, Lewis JW, Woods JH, Traynor JR. BU48: A novel buprenorphine analogue that exhibits delta-opioid mediated convulsions but not delta-opioid mediated antinociception in mice. Journal of Pharmacology and Experimental Therapeutics 2000 Sep; 294(3): 1195–1200. PMID 10945877
  3. ^ Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? Japanese Journal of Pharmacology. 2002 Sep;90(1):1-6. PMID 12396021


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