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Bacteriophage Qβ: Wikis

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Bacteriophage Qβ
Virus classification
Group: Group IV ((+)ssRNA)
Family: Leviviridae
Genus: Bacteriophage Qβ

Bacteriophage Qβ is an icosahedral virus with a diameter of 25 nm. Its host is Escherichia Coli. Qβ enters its host cell through the side of the F pilus.

Genetics

The genome of Qβ is 4218 nucleotides long. The genome has three open reading frames and encodes four proteins: A1, A2, CP and qβ replicase. The genome is highly structured, which regulates gene expression and protects the genome from host RNAses.

A2

A2 is called the maturation protein due to its lysis activity. One copy of A2 is present per virion. The mechanism of lysis is similar to that of penicillin; A2 inhibits the formation of peptidoglycan by inhibiting the enzyme MurA, which catalyzes the first committed step of peptidoglycan synthesis.

A2 also functions in host cell recognition and cell entry. When A2 binds to the sex pilus of the bacterium, A2 cleaves and forms a pore into the host.


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