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Bambuterol: Wikis

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Bambuterol
Systematic (IUPAC) name
(RS)-5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diyl bis(dimethylcarbamate)
Identifiers
CAS number 81732-46-9
ATC code R03CC12
PubChem 54766
ChemSpider 49466
Chemical data
Formula C18H29N3O5 
Mol. mass 367.44 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 20%
Metabolism Hepatic, extensive
Further metabolized to terbutaline by plasma cholinesterase
Half life 13 hours (bambuterol)
21 hours (terbutaline)
Excretion Renal
Therapeutic considerations
Pregnancy cat. Unknown
Legal status Prescription only
Routes Oral
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Bambuterol (INN, marketed by AstraZeneca under the trade names Bambec and Oxeol) is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.

Contents

Dosage:

  • children: 4 to 5 mg once daily -
  • adults: 10 mg once daily.

Availability of bambuterol:

4 mg, 5 mg & 10 mg. tablets.

Breast Feeding:

It is not known whether bambuterol passes into breast milk.

Pregnancy:

Risks - Benefits ratio must be evaluated by a qualified medical practitioner.

side effects of bambuterol

fatigue, nausea, palpitations, headache, dizziness and termor

Drug Interactions:

  • Succinylcholine, MOIs - Monomine oxidase inhibitors, b-blockers, corticosteroids, diuretics, muscles relaxants, sympathomimetic xenathine derivatives.

Contra-indications:

Hepatic impairment, liver cirrhosis or severely impaired liver function.

Special precautions:

Dose should be reduced in patients with severely impaired renal function - patients with genetic deficiencies of plasma cholinesterase - patients with severe ischamic heart disease.

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