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Bendroflumethiazide: Wikis

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Bendroflumethiazide
Systematic (IUPAC) name
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2 H-1,2,4- benzothiadiazine-7-sulfonamide
Identifiers
CAS number 73-48-3
ATC code C03AA01
PubChem 2315
DrugBank APRD00666
ChemSpider 2225
Chemical data
Formula C 15H14F3N3O4S2  
Mol. mass 421.415 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 100%
Protein binding 96%
Metabolism extensive
Half life 3-4 hours[1]
Excretion  ?
Therapeutic considerations
Pregnancy cat. Risk neonatal thrombocytopenia in 3rd trimester[2]
Legal status POM (UK)
Routes Oral
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Bendroflumethiazide (INN), formerly bendrofluazide (BAN), is a thiazide diuretic used to treat hypertension.

It is also a fairly cheap drug, made cheap through mass production. Normal pharmaceutical trade prices vary from £0.10 - £0.20 for a 28 calendar pack of Bendroflumethiazide 2.5 tablets. Bendroflumethiazide (bendrofluazide) is a thiazide diuretic which works by inhibiting sodium absorption at the beginning of the distal convoluted tubule (DCT). Potassium is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Common adverse effects


Rare adverse effects

References

  1. ^ Ed. Sean C. Sweetman, ed. Martindale: The complete drug reference (33 ed.). Pharmaceutical Press.  
  2. ^ BNF 45 March 2003
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