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Benedikt syndrome
Classification and external resources
ICD-10 G46.3
ICD-9 344.89
DiseasesDB 32780

Benedikt syndrome, also called Benedikt's syndrome or paramedian midbrain syndrome, is a rare type of posterior circulation stroke of the brain, with a range of neurological symptoms affecting the midbrain, cerebellum and other related structures.



It is characterized by the presence of an CN III oculomotor nerve palsy and contralateral hemiparesis (weakness) and cerebellar ataxia including tremor. Neuroanatomical structures affected include CNIII nucleus, Red nucleus, corticospinal tracts, brachium conjunctivum, and cerebellum.


Benedikt syndrome is caused by a lesion ( infarction, hemorrhage, tumor, or tuberculosis) in the tegmentum of the midbrain and cerebellum. Specifically, the median zone is impaired. It can result from occlusion of the posterior cerebral artery.[1]


Deep brain stimulation may provide relief from some symptoms of Benedikt syndrome, particularly the tremors associated with the disorder.[2]


  1. ^ Akdal G, Kutluk K, Men S, Yaka E (Jan 2005). "Benedikt and "plus-minus lid" syndromes arising from posterior cerebral artery branch occlusion". Journal of the neurological sciences 228 (1): 105–107. doi:10.1016/j.jns.2004.09.029. PMID 15607218.  
  2. ^ Bandt SK, Anderson D, Biller J (Oct 2008). "Deep brain stimulation as an effective treatment option for post-midbrain infarction-related tremor as it presents with Benedikt syndrome". Journal of neurosurgery 109 (4): 635–639. doi:10.3171/JNS/2008/109/10/0635. PMID 18826349.  

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