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Benfluorex
Systematic (IUPAC) name
(RS)-2-({1-[3-(trifluoromethyl)phenyl]propan- 2-yl}amino)ethyl benzoate
Identifiers
CAS number 23602-78-0
ATC code A10BX06
PubChem 2318
ChemSpider 2228
Chemical data
Formula C 19H20F3NO2  
Mol. mass 351.363 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral
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Benfluorex is an anorectic and hypolipidemic agent. Clinical studies have shown it may improve glycemic control and decrease insulin resistance in people with poorly controlled type 2 diabetes;[1][2] it is marketed in France as an adjuvant antidiabetic.

On 18 December 2009 the European Medicines Agency (EMEA) has recommended the withdrawal of all medicines containing benfluorex in the European Union, because their risks, particularly the risk of heart valve disease (fenfluramine-like cardiovascular side-effects), are greater than their benefits. [3]


Benfluorex is structurally related to fenfluramine.

References

  1. ^ Moulin P, Andre M, Alawi H, et al. (2006). "Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study". Diabetes Care 29 (3): 515–20. doi:10.2337/diacare.29.03.06.dc05-1439. PMID 16505498.   Free full text
  2. ^ Roger P, Auclair J, Drain P (1999). "Addition of benfluorex to biguanide improves glycemic control in obese non-insulin-dependent diabetes: a double-blind study versus placebo". J Diabetes Complications 13 (2): 62–7. doi:10.1016/S1056-8727(98)00004-X. PMID 10432168.  
  3. ^ Press Release European Medicines Agency recommends withdrawal of benfluorex from the market in European Union [1]

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