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Benperidol: Wikis

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Benperidol
Systematic (IUPAC) name
1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
Identifiers
CAS number 983-42-6
ATC code N05AD07
PubChem 16363
ChemSpider 15521
Chemical data
Formula C22H24FN3O2 
Mol. mass 381.443 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status -only (US)
Routes Oral
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Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1]. It is an antipsychotic, which can be used for the treatment of schizophrenia[2], but it is primarily used to control antisocial hypersexual behaviour[3], and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone.[4]

Benperidol was discovered at Janssen Pharmaceutica in 1961.

References

  1. ^ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
  2. ^ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
  3. ^ British National Formulary (49th), British Medical Association 2005 p 183
  4. ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
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