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Bentazepam
Systematic (IUPAC) name
5-phenyl- 3,5a,6,7,8,9-hexahydro- 2H-[1]benzothieno[2,3-e] [1,4]diazepin- 2-one
Identifiers
CAS number 29462-18-8
ATC code none
PubChem 34592
ChemSpider 11248641
Chemical data
Formula C 17H16N2OS 
Mol. mass 296.387 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV(US)
Routes Oral
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Bentazepam (also known as thiadipone) is a drug which is a benzodiazepine analog.[1] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around two and a half hours after oral administration.[2] The elimination half life is between aproximately 2 - 4 hours.[1][3] Bentazepam is effective as an anxiolytic. A severe benzodiazepine overdose with betazepam may result in coma and respiratory failure.[4] Adverse effects include dry mouth, somnolence, asthenia, dyspepsia, constipation, nausea.[5] and Drug-induced lymphocytic colitis has been associated with bentazepam.[6][7] Severe liver damage and hepatitis has also been associated with bentazepam.[8][9][10] Whilst liver failure from bentazepam is considered to be rare, liver function monitoring has been recommended for all patients taking bentazepam.[11]

See also

References

  1. ^ a b Gonzalez López, F; Mariño; Dominguez-Gil (1986). "Pharmacokinetics of tiadipone: a new anxiolytic". International journal of clinical pharmacology, therapy, and toxicology 24 (9): 482–4. PMID 2877954.  
  2. ^ Mariño, EL; Fernandez Lastra; Gonzalez Lopez; Dominguez-Gil; Garcia Santalla; Vorca; Izquierdo; Ledesma-Jimeno (1987). "Parametrization by non-linear regression and bayesian estimation of bentazepam in a multiple dosage regimen in humans". International journal of clinical pharmacology, therapy, and toxicology 25 (11): 627–32. PMID 3429066.  
  3. ^ Colino, CI; Lastra; López; Ledesma; Mariño (1991). "Open-loop feedback control of serum bentazepam concentrations and Bayesian estimation in multiple dosage regimens in patients.". International journal of clinical pharmacology, therapy, and toxicology 29 (11): 457–62. PMID 1800395.  
  4. ^ Rivas López, FA; López Soriano; Mendoza Cerezo; Jiménez Ferré; Azurmendi Rodríguez; De La Rubia Nieto (1989). "Mixed benzodiazepine poisoning and reversal with flumazenil (Ro 15-1788)". Revista espanola de anestesiologia y reanimacion 36 (1): 48–50. PMID 2565591.  
  5. ^ Honorato, J; Rubio; Tristán; Otero; Garrido (1990). "A pharmacovigilance study with bentazepam in a sample of 1046 psychiatric outpatients". Revista de medicina de la Universidad de Navarra 34 (2): 80–8. PMID 1983365.  
  6. ^ Fernández-Bañares, F; Salas; Esteve; Espinós; Forné; Viver (2003). "Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up.". The American journal of gastroenterology 98 (2): 340–7. doi:10.1111/j.1572-0241.2003.07225.x. PMID 12591052.  
  7. ^ De-La-Serna, C; Gil-Grande; Sanromán; Gonzalez; Ruiz-Del-Arbol; Garcia Plaza (1997). "Bentazepam-induced hepatic bridging necrosis.". Journal of clinical gastroenterology 25 (4): 710–1. PMID 9451703.  
  8. ^ Andrade, RJ; Lucena; Kaplowitz; García-Muņoz; Borraz; Pachkoria; García-Cortés; Fernández et al. (2006). "Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry.". Hepatology (Baltimore, Md.) 44 (6): 1581–8. doi:10.1002/hep.21424. PMID 17133470.  
  9. ^ "Utilidad cl�nica del acetato de megestrol para la ganancia de peso en los enfermos con neoplasia y caquexia" (in Spanish). Medicina Cl�nica 120 (17): 678. 2003. http://www.elsevier.es/revistas/ctl_servlet?_f=7064&ip=90.221.211.72&articuloid=13047309&revistaid=2.  
  10. ^ Andrade, RJ; Lucena; Alcantara; Fraile (1994). "Bentazepam-associated chronic liver disease.". Lancet 343 (8901): 860. PMID 7908109.  
  11. ^ Andrade, RJ; Lucena; Aguilar; Lazo; Camargo; Moreno; García-Escaño; Marquez et al. (2000). "Chronic liver injury related to use of bentazepam: an unusual instance of benzodiazepine hepatotoxicity.". Digestive diseases and sciences 45 (7): 1400–4. PMID 10961721.  







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