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Benzydamine: Wikis


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Systematic (IUPAC) name
CAS number 642-72-8
ATC code A01AD02 G02CC03 M01AX07 M02AA05
PubChem 12555
ChemSpider 12036
Chemical data
Formula C19H23N3O 
Mol. mass 309.405 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Protein binding <20%
Half life 13 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. B2(AU)
Legal status OTC(UK)
Routes Oral, topical
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Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat.[1]

It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) is virtually free of any adverse systemic effects.

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.



It is available in a mouth wash named Tantum Verde and Tantum Rosa across Europe.

It is available in gel or oral rinse form with trade name Tantum (Elder Pharmaceutical) in India

In the UK it is available without prescription from pharmacies; it is produced in the UK by Meda Pharmaceuticals under the trade name Difflam, and is available as a spray, oral rinse and cream, and as lozenges.

In Sweden it is sold by Antula Healthcare, under he trade name Zyx, as lozenges.

In Australia it is available from 3M as Difflam-C Alcohol & Colour Free Solution, Difflam 3% Gel, Difflam Extra Strength Gel 5%, Difflam-C Solution, Difflam Solution (including Difflam Throat Spray), Difflam Cream and Difflam Lozenges.[2]

It is sold in eastern Europe without prescription as Tantum Rosa - a vaginal antiseptic and anti-inflammatory, containing 0.5 g of benzydamine hydrochloride to be reconstituted with clean water to a 0.1% (1 mg/mL) solution for vaginal enema/instillation.

In Brazil it is sold over-the-counter under the name "Benflogin", with each box containing 20 pills (50mg each).

In Pakistan it is sold by prescription under the name Tantum Capsule (50mg).

It is available in a cream and gel named Tantum Fort across Egypt by EIPICo.

It is available with prescription as a mouthwash named Novo-Benzydamine (Novopharm) in Canada.

In Mexico it is sold by prescription under the name Vantal as a mouth rinse.

In South Africa it is sold as Andolex/Andolex-C Oral Rinse, Spray and Lozenges and is manufactured by 3M Pharmaceuticals S.A. (Pty) Ltd.[3]


Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.

Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.


There are no contraindications to the use of Benzydamine except for known hypersensitivity.

Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur. Benzydamine may be abused recreationally.[4] In oral dosages of 500 mg to 3000 mg it is a deliriant and CNS stimulant (a cough drop has 3 mg dose), popular in Poland, Brazil and Romania. In Brazil it is very popular and widely used for recreational purposes, particularly among teenagers and as a club drug.[5] A person in a benzydamine trip may experience(because of large dopamine release) a feeling of well-being, euphoria and, in higher doses, hallucinations, paranoia, dry mouth and convulsions. The trip can last up to 8 hours, after that the user becomes tired and quiet, but sleeping is almost impossible. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.[4]


  1. ^ Turnbull RS. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. Journal of the Canadian Dental Association. 1995 Feb;61(2):127-34.
  2. ^ Material Safety Data Sheets for Difflam varieties sold in Australia
  3. ^ 3M Pharmaceuticals S.A. (Pty) Ltd
  4. ^ a b Anand JS, Glebocka ML, Korolkiewicz RP. Recreational abuse with benzydamine hydrochloride (tantum rosa). Clinical Toxicology (Philadelphia, Pa). 2007;45(2):198-9.
  5. ^ Alves L (n.d.). "Benflogin (cloridrato de benzidamina)" (in Portuguese). Brasil Escola.  Retrieved on November 5, 2008.

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