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Benzylpenicillin: Wikis

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Penicillin G
Systematic (IUPAC) name
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2α,5α,6β))-
Identifiers
CAS number 61-33-6 (free acid)
69-57-8 (sodium salt)
ATC code J01CE01 S01AA14 QJ51CE01
PubChem 5904
DrugBank DB01053
Chemical data
Formula C 16H18N2O4S 
Mol. mass 334.4 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 60 %
Metabolism hepatic
Half life 30 min
Excretion renal
Therapeutic considerations
Pregnancy cat. B(US)
Legal status Prescription only
Routes parenteral
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Benzylpenicillin, commonly known as penicillin G, is the gold standard type of penicillin. Penicillin G is typically given by a parenteral route of administration (not orally) because it is unstable in the hydrochloric acid of the stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin. These higher concentrations translate to increased antibacterial activity.

Specific indications for benzylpenicillin include:[1]

References

  1. ^ Rossi S, editor, ed (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3.  
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