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Beta-1 adrenergic receptor: Wikis

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Adrenergic, beta-1-, receptor
Identifiers
Symbols ADRB1; ADRB1R; B1AR; BETA1AR; RHR
External IDs OMIM109630 MGI87937 HomoloGene20171 IUPHAR: β1-adrenoceptor GeneCards: ADRB1 Gene
RNA expression pattern
PBB GE ADRB1 208214 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 153 11554
Ensembl ENSG00000043591 ENSMUSG00000035283
UniProt P08588 Q9CRR2
RefSeq (mRNA) NM_000684 NM_007419
RefSeq (protein) NP_000675 NP_031445
Location (UCSC) Chr 10:
115.79 - 115.8 Mb
Chr 19:
56.78 - 56.78 Mb
PubMed search [1] [2]

The beta-1 adrenergic receptor1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.[1] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein.

Contents

Receptor

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Actions

Actions of the β1 receptor include:

Agonists

Isoprenaline has higher affinity for β1 than noradrenaline, which, in turn, binds with higher affinity than adrenaline. Selective agonists to the beta-1 receptor are:

Antagonists

(Beta blockers) β1-selective ones are:

Mechanism

Gs renders adenylate cyclase activated, resulting in increase of cAMP.

Gene

Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.[1]

Interactions

Beta-1 adrenergic receptor has been shown to interact with DLG4[5] and GIPC1.[6]

See also

References

  1. ^ a b "Entrez Gene: ADRB1 adrenergic, beta-1-, receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153.  
  2. ^ a b c d e Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.   Page 163
  3. ^ a b c d e Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2". Neuroscience (Third ed.). Sunderland, Mass: Sinauer. ISBN 0-87893-725-0.  
  4. ^ American Society of Health-System Pharmacists, Inc. (2005-01-01). "Bisoprolol". MedlinePlus Drug Information. U.S. National Library of Medicine, National Institutes of Health. http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a693024.html. Retrieved 2008-06-06.  
  5. ^ Hu, L A; Tang Y, Miller W E, Cong M, Lau A G, Lefkowitz R J, Hall R A (Dec. 2000). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". J. Biol. Chem. (UNITED STATES) 275 (49): 38659–66. doi:10.1074/jbc.M005938200. ISSN 0021-9258. PMID 10995758.  
  6. ^ Hu, Liaoyuan A; Chen Wei, Martin Negin P, Whalen Erin J, Premont Richard T, Lefkowitz Robert J (Jul. 2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". J. Biol. Chem. (United States) 278 (28): 26295–301. doi:10.1074/jbc.M212352200. ISSN 0021-9258. PMID 12724327.  

External links

Further reading

  • Frielle T, Kobilka B, Lefkowitz RJ, Caron MG (1989). "Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes.". Trends Neurosci. 11 (7): 321–4. doi:10.1016/0166-2236(88)90095-1. PMID 2465637.  
  • Muszkat M (2007). "Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9.". Clin. Pharmacol. Ther. 82 (2): 215–8. doi:10.1038/sj.clpt.6100142. PMID 17329986.  
  • Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). "Chromosomal organization of adrenergic receptor genes.". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–1520. doi:10.1073/pnas.87.4.1516. PMID 2154750.  
  • Forse RA, Leibel R, Gagner M (1989). "The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte.". J. Surg. Res. 46 (1): 41–8. doi:10.1016/0022-4804(89)90180-7. PMID 2536864.  
  • Frielle T, Collins S, Daniel KW, et al. (1987). "Cloning of the cDNA for the human beta 1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7920–7924. doi:10.1073/pnas.84.22.7920. PMID 2825170.  
  • Stiles GL, Strasser RH, Lavin TN, et al. (1983). "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.". J. Biol. Chem. 258 (13): 8443–8449. PMID 6305985.  
  • Hoehe MR, Otterud B, Hsieh WT, et al. (1995). "Genetic mapping of adrenergic receptor genes in humans.". J. Mol. Med. 73 (6): 299–306. doi:10.1007/BF00231616. PMID 7583452.  
  • Elies R, Ferrari I, Wallukat G, et al. (1996). "Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease.". J. Immunol. 157 (9): 4203–4211. PMID 8892658.  
  • Oldenhof J, Vickery R, Anafi M, et al. (1998). "SH3 binding domains in the dopamine D4 receptor.". Biochemistry 37 (45): 15726–36. doi:10.1021/bi981634. PMID 9843378.  
  • Mason DA, Moore JD, Green SA, Liggett SB (1999). "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.". J. Biol. Chem. 274 (18): 12670–4. doi:10.1074/jbc.274.18.12670. PMID 10212248.  
  • Moore JD, Mason DA, Green SA, et al. (1999). "Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.". Hum. Mutat. 14 (3): 271. doi:10.1002/(SICI)1098-1004(1999)14:3<271::AID-HUMU14>3.0.CO;2-Q. PMID 10477438.  
  • Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMID 10535961.  
  • Podlowski S, Wenzel K, Luther HP, et al. (2000). "Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?". J. Mol. Med. 78 (2): 87–93. doi:10.1007/s001090000080. PMID 10794544.  
  • Shiina T, Kawasaki A, Nagao T, Kurose H (2000). "Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors.". J. Biol. Chem. 275 (37): 29082–90. doi:10.1074/jbc.M909757199. PMID 10862778.  
  • Hu LA, Tang Y, Miller WE, et al. (2001). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.". J. Biol. Chem. 275 (49): 38659–66. doi:10.1074/jbc.M005938200. PMID 10995758.  
  • Börjesson M, Magnusson Y, Hjalmarson A, Andersson B (2001). "A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.". Eur. Heart J. 21 (22): 1853–1858. doi:10.1053/euhj.1999.1994. PMID 11052857.  
  • Xu J, Paquet M, Lau AG, et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.  
  • Hu LA, Chen W, Premont RT, et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.". J. Biol. Chem. 277 (2): 1607–1613. doi:10.1074/jbc.M107297200. PMID 11700307.  
  • Ranade K, Jorgenson E, Sheu WH, et al. (2002). "A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.". Am. J. Hum. Genet. 70 (4): 935–42. doi:10.1086/339621. PMID 11854867.  

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