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Beta-1 adrenergic receptor: Wikis


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Adrenergic, beta-1-, receptor
External IDs OMIM109630 MGI87937 HomoloGene20171 IUPHAR: β1-adrenoceptor GeneCards: ADRB1 Gene
RNA expression pattern
PBB GE ADRB1 208214 at tn.png
More reference expression data
Species Human Mouse
Entrez 153 11554
Ensembl ENSG00000043591 ENSMUSG00000035283
UniProt P08588 Q9CRR2
RefSeq (mRNA) NM_000684 NM_007419
RefSeq (protein) NP_000675 NP_031445
Location (UCSC) Chr 10:
115.79 - 115.8 Mb
Chr 19:
56.78 - 56.78 Mb
PubMed search [1] [2]

The beta-1 adrenergic receptor1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.[1] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein.





Actions of the β1 receptor include:


Isoprenaline has higher affinity for β1 than noradrenaline, which, in turn, binds with higher affinity than adrenaline. Selective agonists to the beta-1 receptor are:


(Beta blockers) β1-selective ones are:


Gs renders adenylate cyclase activated, resulting in increase of cAMP.


Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.[1]


Beta-1 adrenergic receptor has been shown to interact with DLG4[5] and GIPC1.[6]

See also


  1. ^ a b "Entrez Gene: ADRB1 adrenergic, beta-1-, receptor".  
  2. ^ a b c d e Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.   Page 163
  3. ^ a b c d e Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2". Neuroscience (Third ed.). Sunderland, Mass: Sinauer. ISBN 0-87893-725-0.  
  4. ^ American Society of Health-System Pharmacists, Inc. (2005-01-01). "Bisoprolol". MedlinePlus Drug Information. U.S. National Library of Medicine, National Institutes of Health. Retrieved 2008-06-06.  
  5. ^ Hu, L A; Tang Y, Miller W E, Cong M, Lau A G, Lefkowitz R J, Hall R A (Dec. 2000). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". J. Biol. Chem. (UNITED STATES) 275 (49): 38659–66. doi:10.1074/jbc.M005938200. ISSN 0021-9258. PMID 10995758.  
  6. ^ Hu, Liaoyuan A; Chen Wei, Martin Negin P, Whalen Erin J, Premont Richard T, Lefkowitz Robert J (Jul. 2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". J. Biol. Chem. (United States) 278 (28): 26295–301. doi:10.1074/jbc.M212352200. ISSN 0021-9258. PMID 12724327.  

External links

Further reading

  • Frielle T, Kobilka B, Lefkowitz RJ, Caron MG (1989). "Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes.". Trends Neurosci. 11 (7): 321–4. doi:10.1016/0166-2236(88)90095-1. PMID 2465637.  
  • Muszkat M (2007). "Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9.". Clin. Pharmacol. Ther. 82 (2): 215–8. doi:10.1038/sj.clpt.6100142. PMID 17329986.  
  • Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). "Chromosomal organization of adrenergic receptor genes.". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–1520. doi:10.1073/pnas.87.4.1516. PMID 2154750.  
  • Forse RA, Leibel R, Gagner M (1989). "The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte.". J. Surg. Res. 46 (1): 41–8. doi:10.1016/0022-4804(89)90180-7. PMID 2536864.  
  • Frielle T, Collins S, Daniel KW, et al. (1987). "Cloning of the cDNA for the human beta 1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7920–7924. doi:10.1073/pnas.84.22.7920. PMID 2825170.  
  • Stiles GL, Strasser RH, Lavin TN, et al. (1983). "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.". J. Biol. Chem. 258 (13): 8443–8449. PMID 6305985.  
  • Hoehe MR, Otterud B, Hsieh WT, et al. (1995). "Genetic mapping of adrenergic receptor genes in humans.". J. Mol. Med. 73 (6): 299–306. doi:10.1007/BF00231616. PMID 7583452.  
  • Elies R, Ferrari I, Wallukat G, et al. (1996). "Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease.". J. Immunol. 157 (9): 4203–4211. PMID 8892658.  
  • Oldenhof J, Vickery R, Anafi M, et al. (1998). "SH3 binding domains in the dopamine D4 receptor.". Biochemistry 37 (45): 15726–36. doi:10.1021/bi981634. PMID 9843378.  
  • Mason DA, Moore JD, Green SA, Liggett SB (1999). "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.". J. Biol. Chem. 274 (18): 12670–4. doi:10.1074/jbc.274.18.12670. PMID 10212248.  
  • Moore JD, Mason DA, Green SA, et al. (1999). "Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.". Hum. Mutat. 14 (3): 271. doi:10.1002/(SICI)1098-1004(1999)14:3<271::AID-HUMU14>3.0.CO;2-Q. PMID 10477438.  
  • Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMID 10535961.  
  • Podlowski S, Wenzel K, Luther HP, et al. (2000). "Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?". J. Mol. Med. 78 (2): 87–93. doi:10.1007/s001090000080. PMID 10794544.  
  • Shiina T, Kawasaki A, Nagao T, Kurose H (2000). "Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors.". J. Biol. Chem. 275 (37): 29082–90. doi:10.1074/jbc.M909757199. PMID 10862778.  
  • Hu LA, Tang Y, Miller WE, et al. (2001). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.". J. Biol. Chem. 275 (49): 38659–66. doi:10.1074/jbc.M005938200. PMID 10995758.  
  • Börjesson M, Magnusson Y, Hjalmarson A, Andersson B (2001). "A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.". Eur. Heart J. 21 (22): 1853–1858. doi:10.1053/euhj.1999.1994. PMID 11052857.  
  • Xu J, Paquet M, Lau AG, et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.  
  • Hu LA, Chen W, Premont RT, et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.". J. Biol. Chem. 277 (2): 1607–1613. doi:10.1074/jbc.M107297200. PMID 11700307.  
  • Ranade K, Jorgenson E, Sheu WH, et al. (2002). "A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.". Am. J. Hum. Genet. 70 (4): 935–42. doi:10.1086/339621. PMID 11854867.  


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