The Full Wiki

More info on Beta-galactoside alpha-2,6-sialyltransferase

Beta-galactoside alpha-2,6-sialyltransferase: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

beta-galactoside alpha-2,6-sialyltransferase
Identifiers
EC number 2.4.99.1
CAS number 9075-81-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology AmiGO / EGO

In enzymology, a beta-galactoside alpha-2,6-sialyltransferase (EC 2.4.99.1) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine \rightleftharpoons CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosamine

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-, and glucosamine.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucos amine alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in n-glycan biosynthesis and glycan structures - biosynthesis 1.

References

  • Bartholomew BA, Jourdian GW, Roseman S (1973). "The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum". J. Biol. Chem. 248: 5751–62. PMID 4723915.  
  • Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH (1970). "Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin". J. Biol. Chem. 245: 759–66. PMID 4313609.  
  • Paulson JC, Beranek WE, Hill RL (1977). "Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose". J. Biol. Chem. 252: 2356–62. PMID 849932.  
  • Schachter H, Narasimhan S, Gleeson P, Vella G (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods. Enzymol. 98: 98–134. doi:10.1016/0076-6879(83)98143-0. PMID 6366476.  
  • Spiro MJ, Spiro RG (1968). "Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase". J. Biol. Chem. 243: 6520–8. PMID 5726897.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message