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Bifemelane: Wikis


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Systematic (IUPAC) name
CAS number 90293-01-9
ATC code N06AX08
PubChem 2377
Chemical data
Formula C 18H23NO 
Mol. mass 269.381
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Bifemelane is a drug with neuroprotective, nootropic and antidepressant effects, acting through altered muscarinic acetylcholine function in the brain.[1][2] It is also useful for the treatment of glaucoma.[3] Bifemelane is structurally related to the antihistamine phenyltoloxamine.



  1. ^ Kondo Y, Ogawa N, Asanuma M, Matsuura K, Nishibayashi K, Iwata E. Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion. Neuroscience Research. 1996 Mar;24(4):409-14. PMID 8861111
  2. ^ Egashira T, Takayama F, Yamanaka Y. Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries. Japanese Journal of Pharmacology. 1996 Sep;72(1):57-65. PMID 8902600
  3. ^ Shigemitsu T, Majima Y. Use of bifemelane hydrochloride in improving and maintaining the visual field of patients with glaucoma. Clinical Therapeutics. 1996 Jan-Feb;18(1):106-13. PMID 8851457


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