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Binedaline
Systematic (IUPAC) name
N,N,N-trimethyl-N-(3-phenylindol-1-yl)ethane-1,2-diamine
Identifiers
CAS number 60662-16-0
ATC code none
PubChem 42509
ChemSpider 38769
Chemical data
Formula C19H24ClN3 
Mol. mass 329.86696 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Binedaline (Ixprim), also called binodaline, is a drug that was being investigated as an antidepressant in the 1980s but never marketed.[1][2] It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 µM) transporters.[3] It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.[3]

References

  1. ^ Faltus; Geerling, FC (1984). "A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression". Neuropsychobiology 12 (1): 34–8. doi:10.1159/000118107. PMID 6239991.  edit
  2. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/books?id=DeX7jgInYFMC&lpg=PA267&pg=PA267#v=onepage&q=&f=false. 
  3. ^ a b Morin; Zini, R; Urien, S; Tillement, JP (1989). "Pharmacological profile of binedaline, a new antidepressant drug". The Journal of pharmacology and experimental therapeutics 249 (1): 288–96. PMID 2540319.  edit
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