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Binospirone
Systematic (IUPAC) name
8-[2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione
Identifiers
CAS number 124756-23-6
ATC code none
PubChem 60769
Chemical data
Formula C 20H26N2O4  
Mol. mass 358.431 g/mol
SMILES eMolecules & PubChem
Synonyms Binospirone
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Binospirone (MDL-73005-EF) is a drug which acts as a partial agonist at 5HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5HT1A receptors.[1] It has anxiolytic effects.[2]

References

  1. ^ Bertrand F, Lehmann O, Galani R, Lazarus C, Jeltsch H, Cassel JC. Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats. Pharmacology, Biochemistry and Behaviour. 2001 Apr;68(4):647-60. PMID 11526961
  2. ^ Moser PC, Tricklebank MD, Middlemiss DN, Mir AK, Hibert MF, Fozard JR. Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam. British Journal of Pharmacology. 1990 Feb;99(2):343-9. PMID 1970269
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