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Bivatuzumab mertansine ?
Monoclonal antibody
Type whole antibody
Source humanized (from mouse)
Target CD44 v6
Identifiers
ATC code none
Chemical data
Formula  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Bivatuzumab mertansine is a combination of bivatuzumab, a humanized monoclonal antibody, and mertansine, a cytotoxic agent. It is designed for the treatment of squamous cell carcinoma.[1]

References

  1. ^ Tijink, BM; Buter, J; De Bree, R; Giaccone, G; Lang, MS; Staab, A; Leemans, CR; Van Dongen, GA (2006). "A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus". Clinical cancer research : an official journal of the American Association for Cancer Research 12 (20 Pt 1): 6064–72. doi:10.1158/1078-0432.CCR-06-0910. PMID 17062682. 
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Bivatuzumab (previously BIWA 4) is a humanized monoclonal antibody against CD44v6.[1] [2]

It is officially described as "immunoglobulin G1 (human-mouse monoclonal BIWA4 γ1-chain anti-human antigen CD44v6), disulfide with human-mouse monoclonal BIWA4 κ-chain, dimer"[3] ,(prior to 2002 it was described as targetting CD44v8[4])

It has been chemically linked to various radioisotopes for use in radiotherapy for, eg. inoperable recurrent or metastatic head and neck cancer.[1]

It has also been linked to a cytotoxic drug mertansine to form Bivatuzumab mertansine.

References


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