Blake Mitchell is a quarterback for the South Carolina Gamecocks football team.

During the 2005 season, Blake Mitchell was diagnosed with a minor case of down-syndrome making it ever more remarkable that he is the starting quarterback for a Division I powerhouse.

On September 13, 2006, South Carolina coach, Steve Spurrier, suspended Mitchell after he was arrested for allegedly assaulting a bouncer at a bar in Columbia.

On September 15, the charges against Mitchell were dropped, and he was reinstated to the team though no longer as the starting quarterback. [352]

On November 4, 2006, Mitchell was inserted back into action, replacing an ineffective Syvelle Newton in the second half against then 12th ranked Arkansas. Down 26-6 at the half Mitchell rallied the Gamecocks with touchdown drives of 92 and 99 yards. The comeback attempt fell just short as the South Carolina lost 26-20.

The following Monday Spurrier named Mitchell the starter for the game against 4th ranked Florida
on November 11. Blake had a solid performance in the game, but the Gamecocks lost 17-16 to the eventual national champions. Two weeks later, however, Mitchell again had a solid performance and rallied his team to defeat the Clemson Tigers in Death Valley, 31-28. This victory was South Carolina's first against Clemson since 2001.

On December 29, 2006, Mitchell led South Carolina to victory in the AutoZone Liberty Bowl over Houston and was named the most valuable player by completing 19 of 29 passes for 319 yards, and four touchdowns, which is a Liberty Bowl record.