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Bombesin-like receptor 3
Symbols BRS3;
External IDs OMIM300107 MGI1100501 HomoloGene1307 IUPHAR: BB3 GeneCards: BRS3 Gene
RNA expression pattern
PBB GE BRS3 207369 at tn.png
More reference expression data
Species Human Mouse
Entrez 680 12209
Ensembl ENSG00000102239 ENSMUSG00000031130
UniProt P32247 O54798
RefSeq (mRNA) NM_001727 NM_009766
RefSeq (protein) NP_001718 NP_033896
Location (UCSC) Chr X:
135.4 - 135.4 Mb
Chr X:
53.39 - 53.4 Mb
PubMed search [1] [2]

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]



Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally-occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]


  1. ^ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.  
  2. ^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.  
  3. ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1-2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170.  
  4. ^ "Entrez Gene: BRS3 bombesin-like receptor 3".  
  5. ^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.". J. Biol. Chem. 272: 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.  
  6. ^ Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.". Pharmacol. Rev. 60: 1–42. doi:10.1124/pr.107.07108. PMID 18055507.  

Further reading

  • Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.". FEBS Lett. 340 (3): 260–4. doi:10.1016/0014-5793(94)80150-9. PMID 8131855.  
  • Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.  
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells.". Peptides 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519.  
  • Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.". Nature 390 (6656): 165–9. doi:10.1038/36568. PMID 9367152.  
  • Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.". J. Biol. Chem. 273 (22): 13613–24. doi:10.1074/jbc.273.22.13613. PMID 9593699.  
  • Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).". Biochemistry 41 (28): 8954–60. doi:10.1021/bi0202777. PMID 12102638.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.". Lung Cancer 54 (2): 143–8. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.  
  • Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.". Biochem. J. 405 (1): 131–7. doi:10.1042/BJ20061754. PMID 17355223.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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