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Bombesin-like receptor 3: Wikis

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Bombesin-like receptor 3
Identifiers
Symbols BRS3;
External IDs OMIM300107 MGI1100501 HomoloGene1307 IUPHAR: BB3 GeneCards: BRS3 Gene
RNA expression pattern
PBB GE BRS3 207369 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 680 12209
Ensembl ENSG00000102239 ENSMUSG00000031130
UniProt P32247 O54798
RefSeq (mRNA) NM_001727 NM_009766
RefSeq (protein) NP_001718 NP_033896
Location (UCSC) Chr X:
135.4 - 135.4 Mb
Chr X:
53.39 - 53.4 Mb
PubMed search [1] [2]

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]

Contents

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally-occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]

References

  1. ^ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958.  
  2. ^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8383682.  
  3. ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1-2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170.  
  4. ^ "Entrez Gene: BRS3 bombesin-like receptor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680.  
  5. ^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.". J. Biol. Chem. 272: 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.  
  6. ^ Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.". Pharmacol. Rev. 60: 1–42. doi:10.1124/pr.107.07108. PMID 18055507.  

Further reading

  • Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.". FEBS Lett. 340 (3): 260–4. doi:10.1016/0014-5793(94)80150-9. PMID 8131855.  
  • Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.  
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells.". Peptides 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519.  
  • Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.". Nature 390 (6656): 165–9. doi:10.1038/36568. PMID 9367152.  
  • Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.". J. Biol. Chem. 273 (22): 13613–24. doi:10.1074/jbc.273.22.13613. PMID 9593699.  
  • Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).". Biochemistry 41 (28): 8954–60. doi:10.1021/bi0202777. PMID 12102638.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.". Lung Cancer 54 (2): 143–8. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.  
  • Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.". Biochem. J. 405 (1): 131–7. doi:10.1042/BJ20061754. PMID 17355223.  

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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