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Bone morphogenetic protein 3: Wikis


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Bone morphogenetic protein 3 (osteogenic)
Symbols BMP3; BMP-3A
External IDs OMIM112263 MGI88179 HomoloGene927 GeneCards: BMP3 Gene
RNA expression pattern
PBB GE BMP3 208244 at tn.png
More reference expression data
Species Human Mouse
Entrez 651 110075
Ensembl ENSG00000152785 ENSMUSG00000029335
UniProt P12645 Q149J9
RefSeq (mRNA) NM_001201 NM_173404
RefSeq (protein) NP_001192 NP_775580
Location (UCSC) Chr 4:
82.17 - 82.19 Mb
Chr 5:
99.09 - 99.12 Mb
PubMed search [1] [2]

Bone morphogenetic protein 3 is a protein that in humans is encoded by the BMP3 gene.[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.


Further reading

  • Dickinson ME, Kobrin MS, Silan CM, et al. (1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.". Genomics 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.  
  • Tabas JA, Zasloff M, Wasmuth JJ, et al. (1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3.". Genomics 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.  
  • Paralkar VM, Nandedkar AK, Pointer RH, et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen.". J. Biol. Chem. 265 (28): 17281–4. PMID 2211625.  
  • Rosen V, Wozney JM, Wang EA, et al. (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone.". Connect. Tissue Res. 20 (1-4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.  
  • Wozney JM, Rosen V, Celeste AJ, et al. (1989). "Novel regulators of bone formation: molecular clones and activities.". Science 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.  
  • Faucheux C, Ulysse F, Bareille R, et al. (1998). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation.". Biochem. Biophys. Res. Commun. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.  
  • Daluiski A, Engstrand T, Bahamonde ME, et al. (2001). "Bone morphogenetic protein-3 is a negative regulator of bone density.". Nat. Genet. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004.  
  • Jin Y, Lu HB, Liong E, et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.". Histol. Histopathol. 16 (4): 1013–9. PMID 11642720.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kloen P, Di Paola M, Borens O, et al. (2004). "BMP signaling components are expressed in human fracture callus.". Bone 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.  
  • Kang Q, Sun MH, Cheng H, et al. (2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery.". Gene Ther. 11 (17): 1312–20. doi:10.1038/ PMID 15269709.  
  • Chen AL, Fang C, Liu C, et al. (2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage.". J. Orthop. Res. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


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