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Bretylium: Wikis

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Bretylium
Systematic (IUPAC) name
N-(2-bromobenzyl)-N,N-dimethylethanaminium
Identifiers
CAS number 59-41-6
ATC code C01BD02
PubChem 2431
DrugBank APRD00830
ChemSpider 2337
Chemical data
Formula C 11H17BrN+
Mol. mass 243.163 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability NA
Protein binding NA
Metabolism None
Half life 7-8 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat. C(AU) C(US)
Legal status -only (US)
Routes IV, IM
 Yes check.svgY(what is this?)  (verify)

Bretylium (also bretylium tosylate) is an antiarrhythmic agent.[1] It blocks the release of noradrenaline from the peripheral sympathetic nervous system.

It was patented in 1978. [2]

Uses

It is used in emergency medicine, cardiology, & other specialties for the acute management of ventricular tachycardia & ventricular fibrillation. [3]

It is contraindicated in patients with AV (atrioventricular) heart block or digoxin toxicity.

Bretylium is only used in an ICU setting and should not be used elsewhere due to its dramatic actions and its predominant side effect of hypotension.

References

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