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Brivaracetam
Brivaracetam.svg
Brivaracetam3d.png
IUPAC name
Identifiers
CAS number
PubChem 9837243
SMILES
InChI
InChI key MSYKRHVOOPPJKU-BDAKNGLRBT
ChemSpider ID 8012964
Properties
Molecular formula C11H20N2O2
Molar mass 212.29 g mol−1
Pharmacology
Routes of
administration
Oral
Legal status


?(US)

Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Brivaracetam, the 4-n-propyl analog of levetiracetam, is a racetam derivative with anticonvulsant properties.[1][2] Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle protein SV2.[3] Phase II clinical trials in adult patients with refractory partial seizures were promising. The drug is currently undergoing Phase III clinical trials.[4]

References

  1. ^ von Rosenstiel P (2007). "Brivaracetam (UCB 34714)". Neurotherapeutics 4 (1): 84–7. doi:10.1016/j.nurt.2006.11.004. PMID 17199019.  
  2. ^ Malawska B, Kulig K (2005). "Brivaracetam UCB". Curr Opin Investig Drugs 6 (7): 740–746. PMID 16044671.  
  3. ^ Rogawski MA, Bazil CW (2008). "New molecular targets for antiepileptic drugs: α2δ, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep 8 (4): 345–352. doi:10.1007/s11910-008-0053-7. PMID 18590620.  
  4. ^ Rogawski M (2008). "Brivaracetam: a rational drug discovery success story". Br J Pharmacol 154: 1555. doi:10.1038/bjp.2008.221. PMID 18552880.  
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