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Brofaromine: Wikis

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Systematic (IUPAC) name
CAS number 63638-91-5
ATC code none
PubChem 44571
ChemSpider 40549
Chemical data
Formula C 14H16BrNO2  
Mol. mass 310.186 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Protein binding 98%
Metabolism  ?
Half life 9 to 14 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Brofaromine (Consonar) is a reversible inhibitor of monoamine oxidase A primarily useful in the treatment of depression and anxiety. Brofaromine also has serotonin reuptake inhibitory properties and its dual pharmacologic effects offer promise in the treatment of a wide spectrum of depressed patients while producing less severe anticholinergic side effects in comparison with standard drugs although it is not commercially available and is not being actively researched, possibly due to a lack of financial interest.[1]


Brofaromine is a reversible inhibitor of monoamine oxidase A (RIMA, a type of monoamine oxidase inhibitor (MAOI)) and acts on epinephrine (adrenaline), norepinephrine (noradrenaline), serotonin, and dopamine. Unlike standard MAOIs, possible side effects do not include cardiovascular complications (hypertension) with encephalopathy, liver toxicity or hyperthermia.


  1. ^ Lotufo-Neto F, Trivedi M, Thase ME (1999). "Meta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression". Neuropsychopharmacology 20 (3): 226–47. doi:10.1016/S0893-133X(98)00075-X. PMID 10063483.   Free full text

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