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Bromantane
Systematic (IUPAC) name
N-(4-bromophenyl)adamantan-2-amine
Identifiers
CAS number 87913-26-6
ATC code none
PubChem 4660557
Chemical data
Formula C 16H20BrN 
Mol. mass 306.246 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal
Routes  ?

Bromantane is a stimulant drug developed in Russia during the late 1980s,[1][2] which acts mainly by inhibiting the reuptake of both dopamine and serotonin in the brain,[3][4][5][6] although it also has anticholinergic effects at very high doses.[7][8] It was used as a doping agent to enhance athletic performance, and several athletes tested positive for the drug at the 1996 Atlanta Olympic Games,[9] following which it was added to the banned list. Research on this class of drugs has been fairly extensive and a large family of derivatives are known, although bromantane remains the best studied,[10] and human trials continue for applications such as increasing endurance under extreme conditions.[11]

References

  1. ^ Krapivin SV, Sergeeva SA, Morozov IS. A quantitative pharmaco-electroencephalographic analysis of the action of bromantane. (Russian) Biulleten Eksperimental'noi Biologii i Meditsiny. 1993 Nov;116(11):515-8. PMID 8312546
  2. ^ I.S. Morozov, I.A. Ivanova and T.A. Lukicheva (2001). "Search for New Drugs: Actoprotector and Adaptogen properties of Adamantane Derivatives (A Review)". Pharma. Chem. J. 35: 235–238.  
  3. ^ Grekhova TV, Gaĭnetdinov RR, Sotnikova TD, Krasnykh LM, Kudrin VS, Sergeeva SA, Morozov IS. The effect of bromantane, a new immunostimulant with psychostimulating action, on release and metabolism of dopamine in the dorsal striatum of freely moving rats: a microdialysis study. (Russian) Biulleten Eksperimental'noi Biologii i Meditsiny. 1995 Mar;119(3):302-4. PMID 7795203
  4. ^ Kudrin VS, Sergeeva SA, Krasnykh LM, Miroshnichenko II, Grekhova TV, Gaĭnetdinov RR. The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain. (Russian) Eksperimental'naia i Klinicheskaia Farmakologiia. 1995 Jul-Aug;58(4):8-11. PMID 7580761
  5. ^ Morozov IS, Pukhova GS, Avdulov NA, Sergeeva SA, Spasov AA, Iezhitsa IN. The mechanisms of the neurotropic action of bromantan. (Russian) Eksperimental'naia i Klinicheskaia Farmakologiia. 1999 Jan-Feb;62(1):11-4. PMID 10198757
  6. ^ Seredenin SB, Miramedova AG. Analysis of pharmacological properties of bromantane. (Russian) Biulleten Eksperimental'noi Biologii i Meditsiny. 1999 Nov;128(11):529-31. PMID 10640239
  7. ^ Bugaeva LI, Verovskiĭ VE, Iezhitsa IN, Spasov AA. An acute toxicity study of bromantane. (Russian) Eksperimental'naia i Klinicheskaia Farmakologiia. 2000 Jan-Feb;63(1):57-61. PMID 10763112
  8. ^ Iezhitsa IN, Spasov AA, Bugaeva LI, Morozov IS. Toxic effect of single treatment with bromantane on neurological status of experimental animals. (Russian) Biulleten Eksperimental'noi Biologii i Meditsiny. 2002 Apr;133(4):380-3. PMID 12124651
  9. ^ Burnat P, Payen A, Le Brumant-Payen C, Hugon M, Ceppa F. Bromontan, a new doping agent. Lancet. 1997 Sep 27;350(9082):963-4. PMID 9314900
  10. ^ Morozov IS, Klimova NV, Sergeeva SA, Ivanova IA, Barchukov VG, Kovalev GI, Piatin BM, Avdiunina NI. Adamantane derivatives enhancing body's resistance to emergencies. (Russian) Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. 1999;(3):28-32. PMID 10222828
  11. ^ Viatleva OA, Barchukov VG, Morozov IS, Salenko IuA, Zhirnov EN. The neuro- and psychophysiological effects of bromantane. (Russian) Voenno-Meditsinskii Zhurnal. 2000 Aug;321(8):61-5, 96. PMID 10998997
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