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Brugada syndrome
Classification and external resources

(A) Normal electrocardiogram pattern in the precordial leads V1-3, (B) changes in Brugada syndrome (type B)
ICD-10 I42.8
ICD-9 746.89
OMIM 601144
DiseasesDB 31999
eMedicine med/3736
MeSH D053840

The Brugada syndrome is a genetic disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. It is also known as Sudden Unexpected Death Syndrome[1] (SUDS), and is the most common cause of sudden death in young men without known underlying cardiac disease in Thailand and Laos[2].

Although the ECG findings of Brugada syndrome were first reported[3] among survivors of cardiac arrest in 1989, it was only in 1992 that the Brugada brothers[4] recognized it as a distinct clinical entity, causing sudden death by causing ventricular fibrillation (a lethal arrhythmia) in the heart.

Contents

Genetics and pathophysiology

Type OMIM Mutation Notes
B1 601144 SCN5A alpha subunit of the sodium channel. Current through this channel is commonly referred to as INa. Gain of this channel leads to an unopposed Ito current (KCND2)
B2 611778 GPD1L Glycerol-3-phosphate dehydrogenase like peptide
B3 114205 CACNA1C Alpha subunit of cardiac L-type calcium channel.[5]
B4 600003 CACNB2 Beta-2 subunit of the voltage dependent L-type calcium channel.[5]
B5 604433 KCNE3 which coassembles with KCND3 Beta subunit to KCND3. Modulates the Ito potassium outward current[6]
B6 600235 SCN1B Beta-1 subunit of the sodium channel SCN5A[7]

Approximately 20% of the cases of Brugada syndrome have been shown to be associated with mutation(s) in the gene that encodes for the sodium ion channel in the cell membranes of the muscle cells of the heart (the myocytes). The gene, named SCN5A, is located on the short arm of the third chromosome (3p21). Loss-of-function mutations in this gene lead to a loss of the action potential dome of some epicardial areas of the right ventricle. This results in transmural and epicardial dispersion of repolarization. The transmural dispersion underlies ST-segment elevation and the development of a vulnerable window across the ventricular wall, whereas the epicardial dispersion of repolarization facilitates the development of phase 2 reentry, which generates a phase 2 reentrant extrasystole that captures the vulnerable window to precipitate ventricular tachycardia and/or fibrillation that often results in sudden cardiac death. At present time however, all the reported patients who died because of the disease and were submitted to detailed autopsy study have shown a structural right ventricular pathology underlying the syndrome.

Over 160 mutations in the SCN5A gene have been discovered to date, each having varying mechanisms and effects on function, thereby explaining the varying degrees of penetration and expression of this disorder. [8]

An example of one of the mechanisms in which a loss of function of the sodium channel occurs is a mutation in the gene that disrupts the sodium channel's ability to bind properly to ankyrin-G, an important protein mediating interaction between ion channels and cytoskeletal elements. Very recently a mutation in a second gene, Glycerol-3-phosphate dehydrogenase 1-like gene (GPD1L) has been shown to result in Brugada Syndrome in a large multigenerational family (London, 2006). This gene acts as an ion channel modulator in the heart, although the exact mechanism is not yet understood.

Recently Antzelevitch has identified mutations in the L-type calcium channel subunits (CACNA1C (A39V and G490R) and CACNB2 (S481L)) leading to ST elevation and a relatively short QT interval (below 360 msec).[9] For a comprehensive list of all mutations see [8]

This condition is inherited in an autosomal dominant pattern and is more common in males. In addition it has a higher prevalence in most Asian populations.

Genetic testing for Brugada syndrome is clinically available and may help confirm a diagnosis in patients suspected of having Brugada syndrome, as well as differentiate between relatives who are at-risk for the disease and those who are not (Overview of Brugada Syndrome Genetic Testing).

Electrocardiography

ECG pattern in Brugada syndrome. According to a recent consensus document, type 1 ST segment elevation either spontaneously present or induced with Ajmaline/Flecainide test is considered diagnostic. Type 1 and 2 may lead to suspicion but drug challenge is required for diagnosis. The ECGs in the right and left panels are from the same patient before (right panel, type 1) and after (left panel, type 1) endovenous administration of 1 mg/kg of Ajmaline during 10 minutes.

In some cases, the disease can be detected by observing characteristic patterns on an electrocardiogram, which may be present all the time, or might be elicited by the administration of particular drugs (e.g., Class IC antiarrhythmic drugs that blocks sodium channels and causing appearance of ECG abnormalities - ajmaline, flecainide) or resurface spontaneously due to as yet unclarified triggers.

Brugada syndrome has 3 different ECG patterns. Type 1 has a coved type ST elevation with at least 2 mm J-point elevation a gradually descending ST segment and a negative T-wave. Type 2 has a saddle back pattern with a least 2 mm J-point elevation and at least 1 mm ST elevation with a positive or biphasic T-wave. Type 2 pattern can occasionally be seen in healthy subjects. Type 3 has a saddle back pattern with less than 2 mm J-point elevation and less than 1 mm ST elevation with a positive T-wave. Type 3 pattern is not uncommon in healthy subjects. The pattern seen on the ECG is persistent ST elevations in the electrocardiographic leadsV1-V3 with a right bundle branch block (RBBB) appearance with or without the terminal S waves in the lateral leads that are associated with a typical RBBB. A prolongation of the PR interval (a conduction disturbance in the heart) is also frequently seen.The electrocardiogram can fluctuate over time, depending on the autonomic balance and the administration of antiarrhythmic drugs. Adrenergic stimulation decreases the ST segment elevation, while vagal stimulation worsens it. (There is a case report of a patient who died while shaving, presumed due to the vagal stimulation of the carotid sinus massage) The administration of class Ia, Ic and III drugs increases the ST segment elevation, and also fever. Exercise decreases ST segment elevation in some patients but increases it in others (after exercise when the body temperature has risen). The changes in heart rate induced by atrial pacing are accompanied by changes in the degree of ST segment elevation. When the heart rate decreases, the ST segment elevation increases and when the heart rate increases the ST segment elevation decreases. However, the contrary can also be observed.

Treatment

The cause of death in Brugada syndrome is ventricular fibrillation.The episodes of syncope (fainting) and sudden death (aborted or not) are caused by fast polymorphic ventricular tachycardias or ventricular fibrillation. These arrhythmias appear with no warning. While there is no exact treatment modality that reliably and totally prevents ventricular fibrillation from occurring in this syndrome, treatment lies in termination of this lethal arrhythmia before it causes death. This is done via implantation of an implantable cardioverter-defibrillator (ICD), which continuously monitors the heart rhythm and will defibrillate an individual if ventricular fibrillation is noted. Some recently performed studies had evaluated the role of quinidine, a Class Ia antiarrhythmic drug, for decreasing VF episodes occurring in this syndrome. Quinidine was found to decrease number of VF episodes and correcting spontaneous ECG changes, possibly via inhibiting Ito channels.[10] Those with risk factors for coronary artery disease may require an angiogram before ICD implantation.

See also

References

  1. ^ Hong K, Berruezo-Sanchez A, Poungvarin N, et al. (January 2004). "Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected death syndrome mutation in SCN5A:". J. Cardiovasc. Electrophysiol. 15 (1): 64–9. doi:10.1046/j.1540-8167.2004.03341.x. PMID 15028074. 
  2. ^ Brugada J, Brugada P, Brugada R (July 1999). "The syndrome of right bundle branch block ST segment elevation in V1 to V3 and sudden death--the Brugada syndrome". Europace 1 (3): 156–66. doi:10.1053/eupc.1999.0033. PMID 11225790. 
  3. ^ Martini B, Nava A, Thiene G, et al. (December 1989). "Ventricular fibrillation without apparent heart disease: description of six cases". Am. Heart J. 118 (6): 1203–9. doi:10.1016/0002-8703(89)90011-2. PMID 2589161. 
  4. ^ Brugada P, Brugada J (November 1992). "Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report". J. Am. Coll. Cardiol. 20 (6): 1391–6. PMID 1309182. 
  5. ^ a b Antzelevitch C, Pollevick GD, Cordeiro JM, et al. (2007). "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death". Circulation 115 (4): 442–229. doi:10.1161/CIRCULATIONAHA.106.668392. PMID 17224476. 
  6. ^ Delpon E, Cordeiro JM, Núñez L, et al. (2008). "Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome". Circulation Arrhythmia and Electrophysiology 1 (3): 209–18. doi:10.1161/CIRCEP.107.748103. PMID 19122847. 
  7. ^ Watanabe H, Koopmann TT, Le Scouarnec S, et al. (June 2008). "Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans". J. Clin. Invest. 118 (6): 2260–8. doi:10.1172/JCI33891. PMID 18464934. 
  8. ^ a b Hedley PL; Jorgensen P; Schlamowitz S; et al. (2009). "Brugada syndrome". Human Mutation 30 (9): 1256-66. PMID 19606473. 
  9. ^ Antzelevitch C (2007). "Genetic basis of Brugada syndrome". Heart rhythm : the official journal of the Heart Rhythm Society 4 (6): 756–7. doi:10.1016/j.hrthm.2007.03.015. PMID 17556198. 
  10. ^ Belhassen B, Glick A, Viskin S (2004). "Efficacy of quinidine in high-risk patients with Brugada syndrome". Circulation 110 (13): 1731–7. doi:10.1161/01.CIR.0000143159.30585.90. PMID 15381640. 

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