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Burimamide
Burimamide-2D-skeletal.png
IUPAC name
Identifiers
CAS number 34970-69-9
PubChem 3032915
SMILES
InChI
InChI key HXRBAVXGYZUSED-UHFFFAOYAJ
ChemSpider ID 2297780
Properties
Molecular formula C9H16N4S
Molar mass 212.32 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Burimamide is an antagonist at the H2 and H3 histamine receptors. It is largely inactive as an H2 antagonist at physiological pH,[1] but its H3 affinity is 100x higher. It is a thiourea derivative.

Burimamide was first developed by scientists at Smith, Kline & French (SK&F; now GlaxoSmithKline) in their intent to develop a histamine antagonist for the treatment of peptic ulcers.[2] The discovery of buriamide ultimately led to the development of cimetidine (Tagamet).[2]

See also

References

  1. ^ J. P. Clayden, N. Greeves, S. G. Warren, P. D. Wothers (2000), Organic Chemistry (1st ed.), Oxford: Oxford University Press, p. 205, ISBN 978-0-19-850346-0  
  2. ^ a b "Tagamet: A medicine that changed people's lives". American Chemical Society. 2004. http://acswebcontent.acs.org/landmarks/tagamet/tagamet.html. Retrieved 2009-09-06.  
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