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C-8813
Systematic (IUPAC) name
trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
Identifiers
CAS number  ?
ATC code  ?
PubChem 11058633
Chemical data
Formula C 20H26BrNOS 
Mol. mass 408.394 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal
Routes  ?

C-8813 is a potent μ-opioid agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans isomer was found to be around 591x more potent than morphine in animal studies.[1]

C-883 is claimed to be similarly potent at the delta opioid receptor (DOR).[1]

Considering that C-883 is said to only be thrice the potency of μ-selective fentanyl, it is somewhat strange that bromadol is said to be 10,000 times the potency of morphine.

Clearly the thiophene is uglier but it is suggestive of the possibility that the 10,000 figure quoted by Lednicer should be re-examined.

C-8813 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.

See also

References

  1. ^ a b Liu, ZH; Jin; Dai; Chen; Zhang; Chi (2003). "Opioid activity of C8813, a novel and potent opioid analgesic". Life sciences 73 (2): 233–41. doi:10.1016/S0024-3205(03)00263-7. PMID 12738037.   edit
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