C-jun: Wikis

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Jun oncogene

PDB rendering based on 1a02.
Available structures
1a02, 1fos, 1jnm, 1jun, 1s9k, 1t2k
Identifiers
Symbols JUN; AP1; c-Jun
External IDs OMIM165160 MGI96646 HomoloGene1679 GeneCards: JUN Gene
RNA expression pattern
PBB GE JUN 201464 x at tn.png
PBB GE JUN 201465 s at tn.png
PBB GE JUN 201466 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3725 16476
Ensembl ENSG00000177606 ENSMUSG00000052684
UniProt P05412 Q3US19
RefSeq (mRNA) NM_002228 NM_010591
RefSeq (protein) NP_002219 NP_034721
Location (UCSC) Chr 1:
59.02 - 59.02 Mb
Chr 4:
94.54 - 94.54 Mb
PubMed search [1] [2]

c-Jun is the name of a gene and protein which, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.[1]

Contents

Interactions

C-jun has been shown to interact with Homeobox protein TGIF1,[2] ERG,[3] Retinoblastoma protein,[4] CREB binding protein,[5] Activating transcription factor 2,[6][7][8] Cofactor of BRCA1,[9] BRCA1,[10] C-Fos,[11][12][13][14][15][16][17] NFE2L1,[17] DDX21,[18] NFE2L2,[17] TATA binding protein,[19] RELA,[14] MAPK8,[20][21][22][23][24][25][26][27] Nuclear receptor co-repressor 2,[28] RFWD2,[29][30] PIN1,[31] FOSL1,[12] Mothers against decapentaplegic homolog 3,[32][33][34] ASCC3,[35] Transcription Factor II B,[19] CSNK2A2,[36] Casein kinase 2, alpha 1,[36] STAT1,[37] BCL6,[38] BCL3,[39] Androgen receptor,[40] STAT3,[37] ETS2,[41] ATF3,[42][43][8] NACA,[44] COP9 constitutive photomorphogenic homolog subunit 5,[45] DNA damage-inducible transcript 3,[46] RBM39,[47] Nuclear receptor coactivator 1,[48][49][50] MyoD,[51] RUNX2[52][53] and RUNX1.[52][53]

References

  1. ^ "Entrez Gene: JUN jun oncogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3725.  
  2. ^ Pessah, M; Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier J M, Atfi A (May. 2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (11): 6198–203. doi:10.1073/pnas.101579798. ISSN 0027-8424. PMID 11371641.  
  3. ^ Verger, A; Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M (May. 2001). "Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation". J. Biol. Chem. (United States) 276 (20): 17181–9. doi:10.1074/jbc.M010208200. ISSN 0021-9258. PMID 11278640.  
  4. ^ Nishitani, J; Nishinaka T, Cheng C H, Rong W, Yokoyama K K, Chiu R (Feb. 1999). "Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site". J. Biol. Chem. (UNITED STATES) 274 (9): 5454–61. ISSN 0021-9258. PMID 10026157.  
  5. ^ Sano, Y; Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct. 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". J. Biol. Chem. (UNITED STATES) 273 (44): 29098–105. ISSN 0021-9258. PMID 9786917.  
  6. ^ Newell, C L; Deisseroth A B, Lopez-Berestein G (Jul. 1994). "Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene". J. Leukoc. Biol. (UNITED STATES) 56 (1): 27–35. ISSN 0741-5400. PMID 8027667.  
  7. ^ Kara, C J; Liou H C, Ivashkiv L B, Glimcher L H (Apr. 1990). "A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain". Mol. Cell. Biol. (UNITED STATES) 10 (4): 1347–57. ISSN 0270-7306. PMID 2320002.  
  8. ^ a b Hai, T; Curran T (May. 1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 88 (9): 3720–4. ISSN 0027-8424. PMID 1827203.  
  9. ^ Zhong, Hongjun; Zhu Jianhua, Zhang Hao, Ding Lihua, Sun Yan, Huang Cuifen, Ye Qinong (Dec. 2004). "COBRA1 inhibits AP-1 transcriptional activity in transfected cells". Biochem. Biophys. Res. Commun. (United States) 325 (2): 568–73. doi:10.1016/j.bbrc.2004.10.079. ISSN 0006-291X. PMID 15530430.  
  10. ^ Hu, Yan-Fen; Li Rong (Jun. 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMID 12080089.  
  11. ^ Ito, T; Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H (Jan. 2001). "Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers". J. Biol. Chem. (United States) 276 (4): 2852–7. doi:10.1074/jbc.M009633200. ISSN 0021-9258. PMID 11053448.  
  12. ^ a b Pognonec, P; Boulukos K E, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May. 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene (ENGLAND) 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. ISSN 0950-9232. PMID 9160889.  
  13. ^ Glover, J N; Harrison S C (Jan. 1995). "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA". Nature (ENGLAND) 373 (6511): 257–61. doi:10.1038/373257a0. ISSN 0028-0836. PMID 7816143.  
  14. ^ a b Yang, X; Chen Y, Gabuzda D (Sep. 1999). "ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB". J. Biol. Chem. (UNITED STATES) 274 (39): 27981–8. ISSN 0021-9258. PMID 10488148.  
  15. ^ Nomura, N; Zu Y L, Maekawa T, Tabata S, Akiyama T, Ishii S (Feb. 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J. Biol. Chem. (UNITED STATES) 268 (6): 4259–66. ISSN 0021-9258. PMID 8440710.  
  16. ^ Finkel, T; Duc J, Fearon E R, Dang C V, Tomaselli G F (Jan. 1993). "Detection and modulation in vivo of helix-loop-helix protein-protein interactions". J. Biol. Chem. (UNITED STATES) 268 (1): 5–8. ISSN 0021-9258. PMID 8380166.  
  17. ^ a b c Venugopal, R; Jaiswal A K (Dec. 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene (ENGLAND) 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. ISSN 0950-9232. PMID 9872330.  
  18. ^ Westermarck, Jukka; Weiss Carsten, Saffrich Rainer, Kast Jürgen, Musti Anna-Maria, Wessely Matthias, Ansorge Wilhelm, Séraphin Bertrand, Wilm Matthias, Valdez Benigno C, Bohmann Dirk (Feb. 2002). "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription". EMBO J. (England) 21 (3): 451–60. ISSN 0261-4189. PMID 11823437.  
  19. ^ a b Franklin, C C; McCulloch A V, Kraft A S (Feb. 1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB". Biochem. J. (ENGLAND) 305 ( Pt 3): 967–74. ISSN 0264-6021. PMID 7848298.  
  20. ^ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. (England) 22 (23): 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMID 14633987.  
  21. ^ Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep. 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. ISSN 1097-2765. PMID 9774977.  
  22. ^ Dérijard, B; Hibi M, Wu I H, Barrett T, Su B, Deng T, Karin M, Davis R J (Mar. 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell (UNITED STATES) 76 (6): 1025–37. ISSN 0092-8674. PMID 8137421.  
  23. ^ Yazgan, Oya; Pfarr Curt M (Aug. 2002). "Regulation of two JunD isoforms by Jun N-terminal kinases". J. Biol. Chem. (United States) 277 (33): 29710–8. doi:10.1074/jbc.M204552200. ISSN 0021-9258. PMID 12052834.  
  24. ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302.  
  25. ^ Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (Apr. 1996). "Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation". J. Biol. Chem. (UNITED STATES) 271 (15): 8971–6. ISSN 0021-9258. PMID 8621542.  
  26. ^ Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell. Sci. (ENGLAND) 108 ( Pt 11): 3599–609. ISSN 0021-9533. PMID 8586671.  
  27. ^ Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (Jul. 1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337–42. ISSN 0027-8424. PMID 9207092.  
  28. ^ Lee, S K; Kim J H, Lee Y C, Cheong J, Lee J W (Apr. 2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". J. Biol. Chem. (UNITED STATES) 275 (17): 12470–4. ISSN 0021-9258. PMID 10777532.  
  29. ^ Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase". Science (United States) 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464.  
  30. ^ Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (May. 2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. (United States) 278 (22): 19682–90. doi:10.1074/jbc.M212681200. ISSN 0021-9258. PMID 12615916.  
  31. ^ Wulf, G M; Ryo A, Wulf G G, Lee S W, Niu T, Petkova V, Lu K P (Jul. 2001). "Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1". EMBO J. (England) 20 (13): 3459–72. doi:10.1093/emboj/20.13.3459. ISSN 0261-4189. PMID 11432833.  
  32. ^ Zhang, Y; Feng X H, Derynck R (Aug. 1998). "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription". Nature (ENGLAND) 394 (6696): 909–13. doi:10.1038/29814. ISSN 0028-0836. PMID 9732876.  
  33. ^ Verrecchia, F; Pessah M, Atfi A, Mauviel A (Sep. 2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation". J. Biol. Chem. (UNITED STATES) 275 (39): 30226–31. doi:10.1074/jbc.M005310200. ISSN 0021-9258. PMID 10903323.  
  34. ^ Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844–9. ISSN 0027-8424. PMID 10220381.  
  35. ^ Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul. 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. (United States) 22 (14): 5203–11. ISSN 0270-7306. PMID 12077347.  
  36. ^ a b Yamaguchi, Y; Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (Aug. 1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. (ENGLAND) 26 (16): 3854–61. ISSN 0305-1048. PMID 9685505.  
  37. ^ a b Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E (Oct. 1999). "Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7138–46. ISSN 0270-7306. PMID 10490649.  
  38. ^ Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". J. Immunol. (United States) 169 (4): 1922–9. ISSN 0022-1767. PMID 12165517.  
  39. ^ Na, S Y; Choi J E, Kim H J, Jhun B H, Lee Y C, Lee J W (Oct. 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. (UNITED STATES) 274 (40): 28491–6. ISSN 0021-9258. PMID 10497212.  
  40. ^ Sato, N; Sadar M D, Bruchovsky N, Saatcioglu F, Rennie P S, Sato S, Lange P H, Gleave M E (Jul. 1997). "Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP". J. Biol. Chem. (UNITED STATES) 272 (28): 17485–94. ISSN 0021-9258. PMID 9211894.  
  41. ^ Basuyaux, J P; Ferreira E, Stéhelin D, Butticè G (Oct. 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". J. Biol. Chem. (UNITED STATES) 272 (42): 26188–95. ISSN 0021-9258. PMID 9334186.  
  42. ^ Pearson, Andree G; Gray Carol W, Pearson John F, Greenwood Jeffrey M, During Matthew J, Dragunow Michael (Dec. 2003). "ATF3 enhances c-Jun-mediated neurite sprouting". Brain Res. Mol. Brain Res. (Netherlands) 120 (1): 38–45. ISSN 0169-328X. PMID 14667575.  
  43. ^ Chen, B P; Wolfgang C D, Hai T (Mar. 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157–68. ISSN 0270-7306. PMID 8622660.  
  44. ^ Moreau, A; Yotov W V, Glorieux F H, St-Arnaud R (Mar. 1998). "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1312–21. ISSN 0270-7306. PMID 9488446.  
  45. ^ Claret, F X; Hibi M, Dhut S, Toda T, Karin M (Oct. 1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature (ENGLAND) 383 (6599): 453–7. doi:10.1038/383453a0. ISSN 0028-0836. PMID 8837781.  
  46. ^ Ubeda, M; Vallejo M, Habener J F (Nov. 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMID 10523647.  
  47. ^ Jung, Dong-Ju; Na Soon-Young, Na Doe Sun, Lee Jae Woon (Jan. 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. (United States) 277 (2): 1229–34. doi:10.1074/jbc.M110417200. ISSN 0021-9258. PMID 11704680.  
  48. ^ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. ISSN 0021-9258. PMID 10567404.  
  49. ^ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. ISSN 0888-8809. PMID 10847592.  
  50. ^ Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. 1998). "Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits". J. Biol. Chem. (UNITED STATES) 273 (27): 16651–4. ISSN 0021-9258. PMID 9642216.  
  51. ^ Bengal, E; Ransone L, Scharfmann R, Dwarki V J, Tapscott S J, Weintraub H, Verma I M (Feb. 1992). "Functional antagonism between c-Jun and MyoD proteins: a direct physical association". Cell (UNITED STATES) 68 (3): 507–19. ISSN 0092-8674. PMID 1310896.  
  52. ^ a b Hess, J; Porte D, Munz C, Angel P (Jun. 2001). "AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element". J. Biol. Chem. (United States) 276 (23): 20029–38. doi:10.1074/jbc.M010601200. ISSN 0021-9258. PMID 11274169.  
  53. ^ a b D'Alonzo, Richard C; Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C (Jan. 2002). "Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation". J. Biol. Chem. (United States) 277 (1): 816–22. doi:10.1074/jbc.M107082200. ISSN 0021-9258. PMID 11641401.  

Further reading

  • Bohmann D, Bos TJ, Admon A, et al. (1988). "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.". Science 238 (4832): 1386–92. doi:10.1126/science.2825349. PMID 2825349.  
  • Rahmsdorf HJ (1997). "Jun: transcription factor and oncoprotein.". J. Mol. Med. 74 (12): 725–47. doi:10.1007/s001090050077. PMID 8974016.  
  • Liu JL, Kung HJ (2001). "Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style.". Virus Genes 21 (1-2): 51–64. doi:10.1023/A:1008132313289. PMID 11022789.  
  • Velazquez Torres A, Gariglio Vidal P (2002). "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]". Rev. Invest. Clin. 54 (3): 231–42. PMID 12183893.  
  • Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (2007). "The activator protein-1 transcription factor in respiratory epithelium carcinogenesis.". Mol. Cancer Res. 5 (2): 109–20. doi:10.1158/1541-7786.MCR-06-0311. PMID 17314269.  

See also

External links

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edit
Jun oncogene
File:PBB Protein FOS image.jpg
PDB rendering based on 1a02.
Identifiers
SymbolsJUN; AP1; c-Jun
External IDsOMIM165160 MGI96646 HomoloGene1679 GeneCards: JUN Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez372516476
EnsemblENSG00000177606ENSMUSG00000052684
UniProtP05412Q3US19
RefSeq (mRNA)NM_002228NM_010591
RefSeq (protein)NP_002219NP_034721
Location (UCSC)Chr 1:
59.02 - 59.02 Mb
Chr 4:
94.54 - 94.54 Mb
PubMed search[1][2]

c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein that is highly similar to the viral protein, and that interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.[1]

Contents

Interactions

C-jun has been shown to interact with Homeobox protein TGIF1,[2] ERG,[3] Retinoblastoma protein,[4] CREB binding protein,[5] Activating transcription factor 2,[6][7][8] Cofactor of BRCA1,[9] BRCA1,[10] C-Fos,[11][12][13][14][15][16][17] NFE2L1,[17] DDX21,[18] NFE2L2,[17] TATA binding protein,[19] RELA,[14] MAPK8,[20][21][22][23][24][25][26][27] Nuclear receptor co-repressor 2,[28] RFWD2,[29][30] PIN1,[31] FOSL1,[12] Mothers against decapentaplegic homolog 3,[32][33][34] ASCC3,[35] Transcription Factor II B,[19] CSNK2A2,[36] Casein kinase 2, alpha 1,[36] STAT1,[37] BCL6,[38] BCL3,[39] Androgen receptor,[40] STAT3,[37] ETS2,[41] ATF3,[42][43][8] NACA,[44] COP9 constitutive photomorphogenic homolog subunit 5,[45] DNA damage-inducible transcript 3,[46] RBM39,[47] Nuclear receptor coactivator 1,[48][49][50] MyoD,[51] RUNX2[52][53] and RUNX1.[52][53]

References

  1. ^ "Entrez Gene: JUN jun oncogene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3725. 
  2. ^ Pessah, M; Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier J M, Atfi A (May. 2001). [Expression error: Unexpected < operator "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity"]. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (11): 6198–203. doi:10.1073/pnas.101579798. ISSN 0027-8424. PMID 11371641. 
  3. ^ Verger, A; Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M (May. 2001). [Expression error: Unexpected < operator "Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation"]. J. Biol. Chem. (United States) 276 (20): 17181–9. doi:10.1074/jbc.M010208200. ISSN 0021-9258. PMID 11278640. 
  4. ^ Nishitani, J; Nishinaka T, Cheng C H, Rong W, Yokoyama K K, Chiu R (Feb. 1999). [Expression error: Unexpected < operator "Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site"]. J. Biol. Chem. (UNITED STATES) 274 (9): 5454–61. doi:10.1074/jbc.274.9.5454. ISSN 0021-9258. PMID 10026157. 
  5. ^ Sano, Y; Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct. 1998). [Expression error: Unexpected < operator "CBP alleviates the intramolecular inhibition of ATF-2 function"]. J. Biol. Chem. (UNITED STATES) 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. ISSN 0021-9258. PMID 9786917. 
  6. ^ Newell, C L; Deisseroth A B, Lopez-Berestein G (Jul. 1994). [Expression error: Unexpected < operator "Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene"]. J. Leukoc. Biol. (UNITED STATES) 56 (1): 27–35. ISSN 0741-5400. PMID 8027667. 
  7. ^ Kara, C J; Liou H C, Ivashkiv L B, Glimcher L H (Apr. 1990). [Expression error: Unexpected < operator "A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain"]. Mol. Cell. Biol. (UNITED STATES) 10 (4): 1347–57. ISSN 0270-7306. PMID 2320002. 
  8. ^ a b Hai, T; Curran T (May. 1991). [Expression error: Unexpected < operator "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity"]. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 88 (9): 3720–4. doi:10.1073/pnas.88.9.3720. ISSN 0027-8424. PMID 1827203. 
  9. ^ Zhong, Hongjun; Zhu Jianhua, Zhang Hao, Ding Lihua, Sun Yan, Huang Cuifen, Ye Qinong (Dec. 2004). [Expression error: Unexpected < operator "COBRA1 inhibits AP-1 transcriptional activity in transfected cells"]. Biochem. Biophys. Res. Commun. (United States) 325 (2): 568–73. doi:10.1016/j.bbrc.2004.10.079. ISSN 0006-291X. PMID 15530430. 
  10. ^ Hu, Yan-Fen; Li Rong (Jun. 2002). [Expression error: Unexpected < operator "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction"]. Genes Dev. (United States) 16 (12): 1509–17. doi:10.1101/gad.995502. ISSN 0890-9369. PMID 12080089. 
  11. ^ Ito, T; Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H (Jan. 2001). [Expression error: Unexpected < operator "Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers"]. J. Biol. Chem. (United States) 276 (4): 2852–7. doi:10.1074/jbc.M009633200. ISSN 0021-9258. PMID 11053448. 
  12. ^ a b Pognonec, P; Boulukos K E, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May. 1997). [Expression error: Unexpected < operator "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity"]. Oncogene (ENGLAND) 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. ISSN 0950-9232. PMID 9160889. 
  13. ^ Glover, J N; Harrison S C (Jan. 1995). [Expression error: Unexpected < operator "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA"]. Nature (ENGLAND) 373 (6511): 257–61. doi:10.1038/373257a0. ISSN 0028-0836. PMID 7816143. 
  14. ^ a b Yang, X; Chen Y, Gabuzda D (Sep. 1999). [Expression error: Unexpected < operator "ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB"]. J. Biol. Chem. (UNITED STATES) 274 (39): 27981–8. doi:10.1074/jbc.274.39.27981. ISSN 0021-9258. PMID 10488148. 
  15. ^ Nomura, N; Zu Y L, Maekawa T, Tabata S, Akiyama T, Ishii S (Feb. 1993). [Expression error: Unexpected < operator "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1"]. J. Biol. Chem. (UNITED STATES) 268 (6): 4259–66. ISSN 0021-9258. PMID 8440710. 
  16. ^ Finkel, T; Duc J, Fearon E R, Dang C V, Tomaselli G F (Jan. 1993). [Expression error: Unexpected < operator "Detection and modulation in vivo of helix-loop-helix protein-protein interactions"]. J. Biol. Chem. (UNITED STATES) 268 (1): 5–8. ISSN 0021-9258. PMID 8380166. 
  17. ^ a b c Venugopal, R; Jaiswal A K (Dec. 1998). [Expression error: Unexpected < operator "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes"]. Oncogene (ENGLAND) 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. ISSN 0950-9232. PMID 9872330. 
  18. ^ Westermarck, Jukka; Weiss Carsten, Saffrich Rainer, Kast Jürgen, Musti Anna-Maria, Wessely Matthias, Ansorge Wilhelm, Séraphin Bertrand, Wilm Matthias, Valdez Benigno C, Bohmann Dirk (Feb. 2002). [Expression error: Unexpected < operator "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription"]. EMBO J. (England) 21 (3): 451–60. doi:10.1093/emboj/21.3.451. ISSN 0261-4189. PMID 11823437. 
  19. ^ a b Franklin, C C; McCulloch A V, Kraft A S (Feb. 1995). [Expression error: Unexpected < operator "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB"]. Biochem. J. (ENGLAND) 305 ( Pt 3): 967–74. ISSN 0264-6021. PMID 7848298. 
  20. ^ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. 2003). [Expression error: Unexpected < operator "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling"]. EMBO J. (England) 22 (23): 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMID 14633987. 
  21. ^ Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep. 1998). [Expression error: Unexpected < operator "ASK1 is essential for JNK/SAPK activation by TRAF2"]. Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977. 
  22. ^ Dérijard, B; Hibi M, Wu I H, Barrett T, Su B, Deng T, Karin M, Davis R J (Mar. 1994). [Expression error: Unexpected < operator "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain"]. Cell (UNITED STATES) 76 (6): 1025–37. doi:10.1016/0092-8674(94)90380-8. ISSN 0092-8674. PMID 8137421. 
  23. ^ Yazgan, Oya; Pfarr Curt M (Aug. 2002). [Expression error: Unexpected < operator "Regulation of two JunD isoforms by Jun N-terminal kinases"]. J. Biol. Chem. (United States) 277 (33): 29710–8. doi:10.1074/jbc.M204552200. ISSN 0021-9258. PMID 12052834. 
  24. ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. 2001). [Expression error: Unexpected < operator "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death"]. J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. 
  25. ^ Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (Apr. 1996). [Expression error: Unexpected < operator "Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation"]. J. Biol. Chem. (UNITED STATES) 271 (15): 8971–6. doi:10.1074/jbc.271.15.8971. ISSN 0021-9258. PMID 8621542. 
  26. ^ Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. 1995). [Expression error: Unexpected < operator "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction"]. J. Cell. Sci. (ENGLAND) 108 ( Pt 11): 3599–609. ISSN 0021-9533. PMID 8586671. 
  27. ^ Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (Jul. 1997). [Expression error: Unexpected < operator "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase"]. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337–42. doi:10.1073/pnas.94.14.7337. ISSN 0027-8424. PMID 9207092. 
  28. ^ Lee, S K; Kim J H, Lee Y C, Cheong J, Lee J W (Apr. 2000). [Expression error: Unexpected < operator "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor"]. J. Biol. Chem. (UNITED STATES) 275 (17): 12470–4. doi:10.1074/jbc.275.17.12470. ISSN 0021-9258. PMID 10777532. 
  29. ^ Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. 2004). [Expression error: Unexpected < operator "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase"]. Science (United States) 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464. 
  30. ^ Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (May. 2003). [Expression error: Unexpected < operator "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity"]. J. Biol. Chem. (United States) 278 (22): 19682–90. doi:10.1074/jbc.M212681200. ISSN 0021-9258. PMID 12615916. 
  31. ^ Wulf, G M; Ryo A, Wulf G G, Lee S W, Niu T, Petkova V, Lu K P (Jul. 2001). [Expression error: Unexpected < operator "Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1"]. EMBO J. (England) 20 (13): 3459–72. doi:10.1093/emboj/20.13.3459. ISSN 0261-4189. PMID 11432833. 
  32. ^ Zhang, Y; Feng X H, Derynck R (Aug. 1998). [Expression error: Unexpected < operator "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription"]. Nature (ENGLAND) 394 (6696): 909–13. doi:10.1038/29814. ISSN 0028-0836. PMID 9732876. 
  33. ^ Verrecchia, F; Pessah M, Atfi A, Mauviel A (Sep. 2000). [Expression error: Unexpected < operator "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation"]. J. Biol. Chem. (UNITED STATES) 275 (39): 30226–31. doi:10.1074/jbc.M005310200. ISSN 0021-9258. PMID 10903323. 
  34. ^ Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. 1999). [Expression error: Unexpected < operator "Smads bind directly to the Jun family of AP-1 transcription factors"]. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844–9. doi:10.1073/pnas.96.9.4844. ISSN 0027-8424. PMID 10220381. 
  35. ^ Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul. 2002). [Expression error: Unexpected < operator "Novel transcription coactivator complex containing activating signal cointegrator 1"]. Mol. Cell. Biol. (United States) 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. ISSN 0270-7306. PMID 12077347. 
  36. ^ a b Yamaguchi, Y; Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (Aug. 1998). [Expression error: Unexpected < operator "Casein kinase II interacts with the bZIP domains of several transcription factors"]. Nucleic Acids Res. (ENGLAND) 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. ISSN 0305-1048. PMID 9685505. 
  37. ^ a b Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E (Oct. 1999). [Expression error: Unexpected < operator "Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation"]. Mol. Cell. Biol. (UNITED STATES) 19 (10): 7138–46. ISSN 0270-7306. PMID 10490649. 
  38. ^ Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. 2002). [Expression error: Unexpected < operator "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene"]. J. Immunol. (United States) 169 (4): 1922–9. ISSN 0022-1767. PMID 12165517. 
  39. ^ Na, S Y; Choi J E, Kim H J, Jhun B H, Lee Y C, Lee J W (Oct. 1999). [Expression error: Unexpected < operator "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation"]. J. Biol. Chem. (UNITED STATES) 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. ISSN 0021-9258. PMID 10497212. 
  40. ^ Sato, N; Sadar M D, Bruchovsky N, Saatcioglu F, Rennie P S, Sato S, Lange P H, Gleave M E (Jul. 1997). [Expression error: Unexpected < operator "Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP"]. J. Biol. Chem. (UNITED STATES) 272 (28): 17485–94. doi:10.1074/jbc.272.28.17485. ISSN 0021-9258. PMID 9211894. 
  41. ^ Basuyaux, J P; Ferreira E, Stéhelin D, Butticè G (Oct. 1997). [Expression error: Unexpected < operator "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner"]. J. Biol. Chem. (UNITED STATES) 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. ISSN 0021-9258. PMID 9334186. 
  42. ^ Pearson, Andree G; Gray Carol W, Pearson John F, Greenwood Jeffrey M, During Matthew J, Dragunow Michael (Dec. 2003). [Expression error: Unexpected < operator "ATF3 enhances c-Jun-mediated neurite sprouting"]. Brain Res. Mol. Brain Res. (Netherlands) 120 (1): 38–45. doi:10.1016/j.molbrainres.2003.09.014. ISSN 0169-328X. PMID 14667575. 
  43. ^ Chen, B P; Wolfgang C D, Hai T (Mar. 1996). [Expression error: Unexpected < operator "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10"]. Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157–68. ISSN 0270-7306. PMID 8622660. 
  44. ^ Moreau, A; Yotov W V, Glorieux F H, St-Arnaud R (Mar. 1998). [Expression error: Unexpected < operator "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription"]. Mol. Cell. Biol. (UNITED STATES) 18 (3): 1312–21. ISSN 0270-7306. PMID 9488446. 
  45. ^ Claret, F X; Hibi M, Dhut S, Toda T, Karin M (Oct. 1996). [Expression error: Unexpected < operator "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors"]. Nature (ENGLAND) 383 (6599): 453–7. doi:10.1038/383453a0. ISSN 0028-0836. PMID 8837781. 
  46. ^ Ubeda, M; Vallejo M, Habener J F (Nov. 1999). [Expression error: Unexpected < operator "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins"]. Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589–99. ISSN 0270-7306. PMID 10523647. 
  47. ^ Jung, Dong-Ju; Na Soon-Young, Na Doe Sun, Lee Jae Woon (Jan. 2002). [Expression error: Unexpected < operator "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors"]. J. Biol. Chem. (United States) 277 (2): 1229–34. doi:10.1074/jbc.M110417200. ISSN 0021-9258. PMID 11704680. 
  48. ^ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). [Expression error: Unexpected < operator "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo"]. J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. ISSN 0021-9258. PMID 10567404. 
  49. ^ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. 2000). [Expression error: Unexpected < operator "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2"]. Mol. Endocrinol. (UNITED STATES) 14 (6): 915–25. doi:10.1210/me.14.6.915. ISSN 0888-8809. PMID 10847592. 
  50. ^ Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. 1998). [Expression error: Unexpected < operator "Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits"]. J. Biol. Chem. (UNITED STATES) 273 (27): 16651–4. doi:10.1074/jbc.273.27.16651. ISSN 0021-9258. PMID 9642216. 
  51. ^ Bengal, E; Ransone L, Scharfmann R, Dwarki V J, Tapscott S J, Weintraub H, Verma I M (Feb. 1992). [Expression error: Unexpected < operator "Functional antagonism between c-Jun and MyoD proteins: a direct physical association"]. Cell (UNITED STATES) 68 (3): 507–19. doi:10.1016/0092-8674(92)90187-H. ISSN 0092-8674. PMID 1310896. 
  52. ^ a b Hess, J; Porte D, Munz C, Angel P (Jun. 2001). [Expression error: Unexpected < operator "AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element"]. J. Biol. Chem. (United States) 276 (23): 20029–38. doi:10.1074/jbc.M010601200. ISSN 0021-9258. PMID 11274169. 
  53. ^ a b D'Alonzo, Richard C; Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C (Jan. 2002). [Expression error: Unexpected < operator "Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation"]. J. Biol. Chem. (United States) 277 (1): 816–22. doi:10.1074/jbc.M107082200. ISSN 0021-9258. PMID 11641401. 

Further reading

  • Bohmann D, Bos TJ, Admon A, et al. (1988). [Expression error: Unexpected < operator "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1."]. Science 238 (4832): 1386–92. doi:10.1126/science.2825349. PMID 2825349. 
  • Rahmsdorf HJ (1997). [Expression error: Unexpected < operator "Jun: transcription factor and oncoprotein."]. J. Mol. Med. 74 (12): 725–47. doi:10.1007/s001090050077. PMID 8974016. 
  • Liu JL, Kung HJ (2001). [Expression error: Unexpected < operator "Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style."]. Virus Genes 21 (1-2): 51–64. doi:10.1023/A:1008132313289. PMID 11022789. 
  • Velazquez Torres A, Gariglio Vidal P (2002). [Expression error: Unexpected < operator "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]"]. Rev. Invest. Clin. 54 (3): 231–42. PMID 12183893. 
  • Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (2007). [Expression error: Unexpected < operator "The activator protein-1 transcription factor in respiratory epithelium carcinogenesis."]. Mol. Cancer Res. 5 (2): 109–20. doi:10.1158/1541-7786.MCR-06-0311. PMID 17314269. 

See also

External links


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