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C3a receptor: Wikis


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From Wikipedia, the free encyclopedia

Complement component 3a receptor 1
Symbols C3AR1; AZ3B; C3AR; HNFAG09
External IDs OMIM605246 MGI1097680 HomoloGene2992 IUPHAR: C3a GeneCards: C3AR1 Gene
RNA expression pattern
PBB GE C3AR1 209906 at tn.png
More reference expression data
Species Human Mouse
Entrez 719 12267
Ensembl ENSG00000171860 ENSMUSG00000040552
UniProt Q16581 Q3U4N3
RefSeq (mRNA) NM_004054 NM_009779
RefSeq (protein) NP_004045 NP_033909
Location (UCSC) Chr 12:
8.1 - 8.11 Mb
Chr 6:
122.81 - 122.82 Mb
PubMed search [1] [2]

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.[1][2]

Although its official name implies it only binds C3a, it also binds C4a.


  1. ^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1-2): 39–43. PMID 8605247.  
  2. ^ Ali H, Panettieri RA (2005). "Anaphylatoxin C3a receptors in asthma". Respir. Res. 6: 19. doi:10.1186/1465-9921-6-19. PMID 15723703.  

Further reading

  • Sim RB, Laich A (2001). "Serine proteases of the complement system.". Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Roglic A, Prossnitz ER, Cavanagh SL, et al. (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure.". Biochim. Biophys. Acta 1305 (1-2): 39–43. PMID 8605247.  
  • Ames RS, Li Y, Sarau HM, et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor.". J. Biol. Chem. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.  
  • Crass T, Raffetseder U, Martin U, et al. (1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.". Eur. J. Immunol. 26 (8): 1944–50. doi:10.1002/eji.1830260840. PMID 8765043.  
  • Ames RS, Nuthulaganti P, Kumar C (1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.". FEBS Lett. 395 (2-3): 157–9. doi:10.1016/0014-5793(96)01018-6. PMID 8898085.  
  • Martin U, Bock D, Arseniev L, et al. (1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes.". J. Exp. Med. 186 (2): 199–207. doi:10.1084/jem.186.2.199. PMID 9221749.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Hollmann TJ, Haviland DL, Kildsgaard J, et al. (1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene.". Mol. Immunol. 35 (3): 137–48. doi:10.1016/S0161-5890(98)00021-2. PMID 9694514.  
  • Lienenklaus S, Ames RS, Tornetta MA, et al. (1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor.". J. Immunol. 161 (5): 2089–93. PMID 9725198.  
  • Davoust N, Jones J, Stahel PF, et al. (1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells.". Glia 26 (3): 201–11. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761.  
  • Settmacher B, Bock D, Saad H, et al. (1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a.". J. Immunol. 162 (12): 7409–16. PMID 10358194.  
  • Feild JA, Foley JJ, Testa TT, et al. (1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15.". FEBS Lett. 460 (1): 53–6. doi:10.1016/S0014-5793(99)01317-4. PMID 10571060.  
  • Petering H, Köhl J, Weyergraf A, et al. (2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a.". J. Immunol. 164 (7): 3783–9. PMID 10725738.  
  • Drouin SM, Kildsgaard J, Haviland J, et al. (2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma.". J. Immunol. 166 (3): 2025–32. PMID 11160252.  
  • Ames RS, Lee D, Foley JJ, et al. (2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.". J. Immunol. 166 (10): 6341–8. PMID 11342658.  
  • Kirchhoff K, Weinmann O, Zwirner J, et al. (2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin.". Immunology 103 (2): 210–7. doi:10.1046/j.1365-2567.2001.01197.x. PMID 11412308.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Reca R, Mastellos D, Majka M, et al. (2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.". Blood 101 (10): 3784–93. doi:10.1182/blood-2002-10-3233. PMID 12511407.  

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