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C4BP (protein): Wikis


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complement component 4 binding protein, alpha
Symbol C4BPA
Alt. symbols C4BP
Entrez 722
HUGO 1325
OMIM 120830
RefSeq NM_000715
UniProt P04003
Other data
Locus Chr. 1 q32
complement component 4 binding protein, beta
Symbol C4BPB
Alt. symbols C4BP
Entrez 725
HUGO 1328
OMIM 120831
RefSeq NM_000716
UniProt P20851
Other data
Locus Chr. 1 q32

C4BP is a protein involved in the complement system. C4BP has a hydra-like structure with a central stalk and seven branching alpha-chains.


It inhibits the action of C4, more specifically the classical pathway. It splits C4 convertase and is a cofactor for factor I which cleaves C4b.

C4BP binds necrotic cells and DNA, to clean up after swelling.

It also binds CD40 on B cells which potentiaties proliferation and costimulation.

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