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calcium channel
Symbols CACNA1G; MGC117234; NBR13
External IDs OMIM604065 MGI1201678 HomoloGene22544 IUPHAR: Cav3.1 GeneCards: CACNA1G Gene
Species Human Mouse
Entrez 8913 12291
Ensembl ENSG00000006283 ENSMUSG00000020866
UniProt O43497 Q6PFV8
RefSeq (mRNA) NM_198376 NM_001112813
RefSeq (protein) NP_938198 NP_033913
Location (UCSC) Chr 17:
45.99 - 46.06 Mb
Chr 11:
94.27 - 94.34 Mb
PubMed search [1] [2]

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene.[1][2][3]



Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[1]

See also


  1. ^ a b "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".  
  2. ^ Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature 391 (6670): 896–900. doi:10.1038/36110. PMID 9495342.  
  3. ^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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