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Calcium channel, voltage-dependent, gamma subunit 4
Symbols CACNG4; MGC11138; MGC24983
External IDs OMIM606404 MGI1859167 HomoloGene8674 GeneCards: CACNG4 Gene
RNA expression pattern
PBB GE CACNG4 221585 at tn.png
PBB GE CACNG4 62987 r at tn.png
PBB GE CACNG4 gnf1h00164 at tn.png
More reference expression data
Species Human Mouse
Entrez 27092 54377
Ensembl ENSG00000075461 ENSMUSG00000020723
UniProt Q9UBN1 Q3UNE8
RefSeq (mRNA) NM_014405 NM_019431
RefSeq (protein) NP_055220 NP_062304
Location (UCSC) Chr 17:
62.39 - 62.46 Mb
Chr 11:
107.55 - 107.61 Mb
PubMed search [1] [2]

Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.[1][2]

L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.[2]


See also


Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Moss FJ, Dolphin AC, Clare JJ (2004). "Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.". BMC neuroscience 4: 23. doi:10.1186/1471-2202-4-23. PMID 14505496.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chu PJ, Robertson HM, Best PM (2002). "Calcium channel gamma subunits provide insights into the evolution of this gene family.". Gene 280 (1-2): 37–48. doi:10.1016/S0378-1119(01)00738-7. PMID 11738816.  
  • Burgess DL, Gefrides LA, Foreman PJ, Noebels JL (2001). "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.". Genomics 71 (3): 339–50. doi:10.1006/geno.2000.6440. PMID 11170751.  
  • Powers PA, Liu S, Hogan K, Gregg RG (1993). "Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location.". J. Biol. Chem. 268 (13): 9275–9. PMID 8387489.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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