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Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma

PDB rendering based on 2ux0.
Available structures
Symbols CAMK2G; CAMK; CAMK-II; CAMKG; FLJ16043; MGC26678
External IDs OMIM602123 MGI88259 HomoloGene15596 GeneCards: CAMK2G Gene
EC number
RNA expression pattern
PBB GE CAMK2G 212669 at tn.png
PBB GE CAMK2G 212757 s at tn.png
More reference expression data
Species Human Mouse
Entrez 818 12325
Ensembl ENSG00000148660 ENSMUSG00000021820
UniProt Q13555 Q923T9
RefSeq (mRNA) NM_001222 XM_980738
RefSeq (protein) NP_001213 XP_985832
Location (UCSC) Chr 10:
75.24 - 75.3 Mb
Chr 14:
19.52 - 19.58 Mb
PubMed search [1] [2]

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.[1]

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.[2]


See also

Ca2+/calmodulin-dependent protein kinase


CAMK2G has been shown to interact with RRAD.[3]


  1. ^ Li X, Nghiem P, Schulman H, Francke U (Feb 1994). "Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14". Cytogenet Cell Genet 66 (2): 113–6. PMID 8287681.  
  2. ^ "Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma".  
  3. ^ Moyers, J S; Bilan P J, Zhu J, Kahn C R (May. 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. (UNITED STATES) 272 (18): 11832–9. ISSN 0021-9258. PMID 9115241.  

Further reading

  • Hook SS, Means AR (2001). "Ca(2+)/CaM-dependent kinases: from activation to function.". Annu. Rev. Pharmacol. Toxicol. 41: 471–505. doi:10.1146/annurev.pharmtox.41.1.471. PMID 11264466.  
  • Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso 47 (3): 241–7. PMID 11889801.  
  • Countaway JL, Nairn AC, Davis RJ (1992). "Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.". J. Biol. Chem. 267 (2): 1129–40. PMID 1309762.  
  • Ikebe M, Reardon S (1990). "Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase.". J. Biol. Chem. 265 (16): 8975–8. PMID 2160950.  
  • Czernik AJ, Pang DT, Greengard P (1987). "Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I.". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7518–22. doi:10.1073/pnas.84.21.7518. PMID 3118371.  
  • Vulliet PR, Woodgett JR, Cohen P (1984). "Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.". J. Biol. Chem. 259 (22): 13680–3. PMID 6150037.  
  • Wen Z, Zhong Z, Darnell JE (1995). "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.". Cell 82 (2): 241–50. doi:10.1016/0092-8674(95)90311-9. PMID 7543024.  
  • Kwiatkowski AP, McGill JM (1995). "Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II.". Gastroenterology 109 (4): 1316–23. doi:10.1016/0016-5085(95)90594-4. PMID 7557101.  
  • Shuai K, Stark GR, Kerr IM, Darnell JE (1993). "A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.". Science 261 (5129): 1744–6. doi:10.1126/science.7690989. PMID 7690989.  
  • Zhu J, Reynet C, Caldwell JS, Kahn CR (1995). "Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.". J. Biol. Chem. 270 (9): 4805–12. doi:10.1074/jbc.270.9.4805. PMID 7876254.  
  • Yakel JL, Vissavajjhala P, Derkach VA, et al. (1995). "Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors.". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1376–80. doi:10.1073/pnas.92.5.1376. PMID 7877986.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suko J, Maurer-Fogy I, Plank B, et al. (1993). "Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.". Biochim. Biophys. Acta 1175 (2): 193–206. doi:10.1016/0167-4889(93)90023-I. PMID 8380342.  
  • de Groot RP, den Hertog J, Vandenheede JR, et al. (1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function.". Embo J. 12 (10): 3903–11. PMID 8404858.  
  • Nghiem P, Saati SM, Martens CL, et al. (1993). "Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues.". J. Biol. Chem. 268 (8): 5471–9. PMID 8449910.  
  • Shimomura A, Ogawa Y, Kitani T, et al. (1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.". J. Biol. Chem. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317.  
  • Wei J, Wayman G, Storm DR (1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo.". J. Biol. Chem. 271 (39): 24231–5. doi:10.1074/jbc.271.39.24231. PMID 8798667.  
  • Tombes RM, Krystal GW (1997). "Identification of novel human tumor cell-specific CaMK-II variants.". Biochim. Biophys. Acta 1355 (3): 281–92. doi:10.1016/S0167-4889(96)00141-3. PMID 9060999.  
  • Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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