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The CAMP test is a test to identify Group B β-streptococci[1][2] based on their formation of a substance (CAMP factor[3 ]) that enlarges the area of hemolysis formed by β-hemolysin from Staphylococcus aureus.

Contents

CAMP factor

Although usually used to identify group "B", there is some evidence that the CAMP factor gene is present in several groups of streptococci, including group "A".[4]

A similar factor has been identified in Bartonella henselae.[5]

Uses

It can be used to identify Streptococcus agalactiae. Though not strongly beta-hemolytic on its own,[6 ] it presents with a wedge-shape in the presence of Staphylococcus aureus.[7 ]

History

It is an acronym for "Christie Atkins Munch-Petersen",[8][9][10] for the three researchers who discovered the phenomenon.[11]

It is often incorrectly reported as the product of four people (counting Munch-Petersen as two people).[12]

The name has no relationship to cAMP.

References

  1. ^ Phillips EA, Tapsall JW, Smith DD (August 1980). "Rapid tube CAMP test for identification of Streptococcus agalactiae (Lancefield group B)". J. Clin. Microbiol. 12 (2): 135–7. PMID 7014603. PMC 273541. http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=7014603.  
  2. ^ Wilkinson HW (July 1977). "CAMP-disk test for presumptive identification of group B streptococci". J. Clin. Microbiol. 6 (1): 42–5. PMID 328534. PMC 274694. http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=328534.  
  3. ^ "Laboratory Demonstrations". http://www1.indstate.edu/thcme/micro/demo1.html. Retrieved 2008-12-12.  
  4. ^ Gase K, Ferretti JJ, Primeaux C, McShan WM (September 1999). "Identification, cloning, and expression of the CAMP factor gene (cfa) of group A streptococci". Infect. Immun. 67 (9): 4725–31. PMID 10456923. PMC 96801. http://iai.asm.org/cgi/pmidlookup?view=long&pmid=10456923.  
  5. ^ Litwin CM, Johnson JM (July 2005). "Identification, cloning, and expression of the CAMP-like factor autotransporter gene (cfa) of Bartonella henselae". Infect. Immun. 73 (7): 4205–13. doi:10.1128/IAI.73.7.4205-4213.2005. PMID 15972511. PMC 1168562. http://iai.asm.org/cgi/pmidlookup?view=long&pmid=15972511.  
  6. ^ "Microbiology Primer: Hemolysis". http://gold.aecom.yu.edu/id/micro/hemolysis.htm. Retrieved 2008-12-12.  
  7. ^ "Streptococcaceae Answers". http://faculty.matcmadison.edu/mljensen/111CourseDocs/111Review/Unit2Reviews/streptococcaceae_answers.htm. Retrieved 2008-12-12.  
  8. ^ Ratner HB, Weeks LS, Stratton CW (August 1986). "Evaluation of spot CAMP test for identification of group B streptococci". J. Clin. Microbiol. 24 (2): 296–7. PMID 3528214. PMC 268893. http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=3528214.  
  9. ^ Nsagha DS, Bello CS, Kandakai-Olukemi YT (January 2000). "Hippurate hydrolysis and Christie, Atkins, Munch-Peterson tests as epidemiological diagnostic tools for Streptococcus agalactiae carriage in pregnancy". East Afr Med J 77 (1): 34–6. PMID 10944837.  
  10. ^ Valanne S, McDowell A, Ramage G, et al. (May 2005). "CAMP factor homologues in Propionibacterium acnes: a new protein family differentially expressed by types I and II". Microbiology (Reading, Engl.) 151 (Pt 5): 1369–79. doi:10.1099/mic.0.27788-0. PMID 15870447. http://mic.sgmjournals.org/cgi/pmidlookup?view=long&pmid=15870447.  
  11. ^ Christie, R., Atkins, NE and Munch-Petersen, E. (1944). A note on a lytic phenomenon shown by group B streptococci. Aust. J. Exp. Biol. Med. Sci. 22, 197-200
  12. ^ "Streptococci". http://pathmicro.med.sc.edu/fox/streptococci.htm. Retrieved 2008-12-12.  
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