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Chromobox homolog 1 (HP1 beta homolog Drosophila )

PDB rendering based on 1ap0.
Available structures
1ap0, 1dz1, 1guw, 1s4z, 2fmm
Symbols CBX1; CBX; HP1-BETA; HP1Hs-beta; M31; MOD1
External IDs OMIM604511 MGI105369 HomoloGene38228 GeneCards: CBX1 Gene
RNA expression pattern
PBB GE CBX1 201518 at tn.png
More reference expression data
Species Human Mouse
Entrez 10951 12412
Ensembl ENSG00000108468 ENSMUSG00000018666
UniProt P83916 Q7TPM0
RefSeq (mRNA) NM_006807 XM_990275
RefSeq (protein) NP_006798 XP_995369
Location (UCSC) Chr 17:
43.5 - 43.53 Mb
Chr 11:
96.61 - 96.62 Mb
PubMed search [1] [2]

Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.[1][2]

Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM][2]



CBX1 has been shown to interact with C11orf30,[3] CBX5,[4] CBX3[4] and SUV39H1.[5]

See also


  1. ^ Furuta K, Chan EK, Kiyosawa K, Reimer G, Luderschmidt C, Tan EM (Aug 1997). "Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis". Chromosoma 106 (1): 11–9. doi:10.1007/s004120050219. PMID 9169582.  
  2. ^ a b "Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )".  
  3. ^ Hughes-Davies, Luke; Huntsman David, Ruas Margarida, Fuks Francois, Bye Jacqueline, Chin Suet-Feung, Milner Jonathon, Brown Lindsay A, Hsu Forrest, Gilks Blake, Nielsen Torsten, Schulzer Michael, Chia Stephen, Ragaz Joseph, Cahn Anthony, Linger Lori, Ozdag Hilal, Cattaneo Elena, Jordanova E S, Schuuring Edward, Yu David S, Venkitaraman Ashok, Ponder Bruce, Doherty Aidan, Aparicio Samuel, Bentley David, Theillet Charles, Ponting Chris P, Caldas Carlos, Kouzarides Tony (Nov. 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell (United States) 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. ISSN 0092-8674. PMID 14651845.  
  4. ^ a b Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.  
  5. ^ Aagaard, L; Laible G, Selenko P, Schmid M, Dorn R, Schotta G, Kuhfittig S, Wolf A, Lebersorger A, Singh P B, Reuter G, Jenuwein T (Apr. 1999). "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31". EMBO J. (ENGLAND) 18 (7): 1923–38. doi:10.1093/emboj/18.7.1923. ISSN 0261-4189. PMID 10202156.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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