The Full Wiki

More info on CCL6

CCL6: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

chemokine (C-C motif) ligand 6
Identifiers
Symbol CCL6
Alt. symbols SCYA6, C10, MRP-1
Entrez 20305
RefSeq NM_009139
UniProt P27784
Other data
Locus Chr. 11 [1]

Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents.

In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in bone marrow cultures that have been stimulated with the cytokine GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin (e.g. the immature myeloid cell lines DA3 and 32D cl3, and the macrophage cell line P388D) that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced.[1] CCL6 can also be induced in the mouse lung by the cytokine interleukin 13.[2] Mouse CCL6 is located on chromosome 11.[3] The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.[2]

References

  1. ^ Orlofsky et al. Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes. Cell Regul. 2 (5), 403-412 (1991).
  2. ^ a b Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.
  3. ^ Berger et al. The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines. DNA Cell Biol. 12 (9), 839-847 (1993)
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message