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Chemokine (C-C motif) receptor 4
Identifiers
Symbols CCR4; CC-CKR-4; CKR4; CMKBR4; ChemR13; HGCN:14099; K5-5; MGC88293; k5-5, ChemR13, CD194
External IDs OMIM604836 MGI107824 HomoloGene21135 IUPHAR: CCR4 GeneCards: CCR4 Gene
RNA expression pattern
PBB GE CCR4 208376 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1233 12773
Ensembl ENSG00000183813 ENSMUSG00000047898
UniProt P51679 Q14A03
RefSeq (mRNA) NM_005508 NM_009916
RefSeq (protein) NP_005499 NP_034046
Location (UCSC) Chr 3:
32.97 - 32.97 Mb
Chr 9:
114.34 - 114.35 Mb
PubMed search [1] [2]

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene.[1][2][3][1][2] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.[3]

References

  1. ^ a b Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem 270 (33): 19495-500. PMID 7642634.  
  2. ^ a b Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics 36 (3): 522-6. doi:10.1006/geno.1996.0498. PMID 8884276.  
  3. ^ a b "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1233.  
  4. ^ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.  
  5. ^ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.  

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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