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Integrin, alpha X (complement component 3 receptor 4 subunit)

PDB rendering based on 1n3y.
Available structures
Symbols ITGAX; CD11C
External IDs OMIM151510 MGI96609 HomoloGene55493 GeneCards: ITGAX Gene
RNA expression pattern
PBB GE ITGAX 210184 at tn.png
More reference expression data
Species Human Mouse
Entrez 3687 16411
Ensembl ENSG00000140678 ENSMUSG00000030789
UniProt P20702 Q3TD13
RefSeq (mRNA) XM_001127869 NM_021334
RefSeq (protein) XP_001127869 NP_067309
Location (UCSC) Chr 16:
31.27 - 31.3 Mb
Chr 7:
127.92 - 127.94 Mb
PubMed search [1] [2]

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a human gene.[1]

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[1]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.


See also


Further reading

  • Stewart M, Thiel M, Hogg N (1996). "Leukocyte integrins.". Curr. Opin. Cell Biol. 7 (5): 690–6. doi:10.1016/0955-0674(95)80111-1. PMID 8573344.  
  • Steinman RM, Pack M, Inaba K (1997). "Dendritic cells in the T-cell areas of lymphoid organs.". Immunol. Rev. 156: 25–37. doi:10.1111/j.1600-065X.1997.tb00956.x. PMID 9176697.  
  • Córbi AL, Lopéz-Rodríguez C (1997). "CD11c integrin gene promoter activity during myeloid differentiation.". Leuk. Lymphoma 25 (5-6): 415–25. PMID 9250811.  
  • Ugarova TP, Yakubenko VP (2001). "Recognition of fibrinogen by leukocyte integrins.". Ann. N. Y. Acad. Sci. 936: 368–85. PMID 11460493.  
  • Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells.". J. Immunol. 144 (3): 934–7. PMID 1967280.  
  • Gaidano G, Bergui L, Schena M, et al. (1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes.". Leukemia 4 (10): 682–7. PMID 1976870.  
  • Corbi AL, Garcia-Aguilar J, Springer TA (1990). "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.". J. Biol. Chem. 265 (5): 2782–8. PMID 2303426.  
  • Corbi AL, Larson RS, Kishimoto TK, et al. (1988). "Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.". J. Exp. Med. 167 (5): 1597–607. doi:10.1084/jem.167.5.1597. PMID 3284962.  
  • Corbi AL, Miller LJ, O'Connor K, et al. (1988). "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.". Embo J. 6 (13): 4023–8. PMID 3327687.  
  • Miller LJ, Wiebe M, Springer TA (1987). "Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.". J. Immunol. 138 (8): 2381–3. PMID 3549901.  
  • Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.". J. Immunol. 152 (9): 4582–9. PMID 7512600.  
  • Lecoanet-Henchoz S, Gauchat JF, Aubry JP, et al. (1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18.". Immunity 3 (1): 119–25. doi:10.1016/1074-7613(95)90164-7. PMID 7621072.  
  • Garcìa-Barcina M, Winnock M, Bidaurrazaga I, et al. (1994). "Detection of cell-adhesion molecules on human liver-associated lymphocytes.". Immunology 82 (1): 95–8. PMID 8045597.  
  • Philippeaux MM, Vesin C, Tacchini-Cottier F, Piguet PF (1996). "Activated human platelets express beta2 integrin.". Eur. J. Haematol. 56 (3): 130–7. PMID 8598231.  
  • de Vree WJ, Fontijne-Dorsman AN, Koster JF, Sluiter W (1996). "Photodynamic treatment of human endothelial cells promotes the adherence of neutrophils in vitro.". Br. J. Cancer 73 (11): 1335–40. PMID 8645576.  
  • Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. doi:10.1006/clin.1997.4462. PMID 9473377.  
  • Shelley CS, Da Silva N, Georgakis A, et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.". Genomics 49 (2): 334–6. doi:10.1006/geno.1998.5232. PMID 9598326.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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