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prominin 1
Identifiers
Symbol PROM1
Alt. symbols PROML1, CD133
Entrez 8842
HUGO 9454
OMIM 604365
RefSeq NM_006017
UniProt O43490
Other data
Locus Chr. 4 p15

CD133 is a glycoprotein also known in humans and rodents as Prominin 1 (PROM1).[1] It is the founding member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localizes to cellular protrusions. CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastomas, neuronal and glial stem cells and some other cell types.[2][3]

References

  1. ^ Corbeil D, Fargeas C, Huttner W (2001). "Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein". Biochem Biophys Res Commun 285 (4): 939–44. doi:10.1006/bbrc.2001.5271. PMID 11467842.  
  2. ^ Corbeil D, Röper K, Hellwig A, Tavian M, Miraglia S, Watt S, Simmons P, Peault B, Buck D, Huttner W (2000). "The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions". J Biol Chem 275 (8): 5512–20. doi:10.1074/jbc.275.8.5512. PMID 10681530.  
  3. ^ Shmelkov S, St Clair R, Lyden D, Rafii S (2005). "AC133/CD133/Prominin-1". Int J Biochem Cell Biol 37 (4): 715–9. doi:10.1016/j.biocel.2004.08.010. PMID 15694831.  
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