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Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Identifiers
Symbol FCGR3A
Alt. symbols FCGR3, FCG3
Entrez 2214
HUGO 3619
OMIM 146740
RefSeq NM_000569
UniProt P08637
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Identifiers
Symbol FCGR3B
Alt. symbols FCGR3, FCG3
Entrez 2215
HUGO 3620
OMIM 610665
RefSeq NM_000570
UniProt O75015
Other data
Locus Chr. 1 q23

CD16 is an Fc receptor.

It is a cluster of differentiation found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages[1]. It can be used to isolate populations of these cells by antibodies directed towards CD16, utilising FACS (fluorescent-activated cell sorting) or MACS (magnetic-activated cell sorting).

Contents

Function

CD16 has been identified as Fc receptors FcγRIIIa and FcγRIIIb. These receptors bind to the Fc portion of IgG antibodies.

Further reading

Immunobiology. 5th ed. Janeway, Charles A.; Travers, Paul; Walport, Mark; Shlomchik, Mark. New York and London: Garland Publishing; c2001.

References

  1. ^ Janeway, C.A., Travers, P., Walport, M., & Shlomchik, M. (2001). Immunobiology 5th ed.. New York: Garland Publishing.

1. Janeway, C.A., Travers, P., Walport, M., & Shlomchik, M. (2001). Immunobiology 5th ed.. New York: Garland Publishing.

External links

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